Drift tube ion mobility

DGE a AC AMS APCI API AP-MALDI APPI ASAP BIRD c CAD CE CF CF-FAB Cl CID cw CZE Da DAPCI DART DC DE DESI DIOS DTIMS EC ECD El ELDI EM ESI ETD eV f FAB FAIMS FD FI FT FTICR two-dimensional gel electrophoresis atto, 10 18 alternating current accelerator mass spectrometry atmospheric pressure chemical ionization atmospheric pressure ionization atmospheric pressure matrix-assisted laser desorption/ionization atmospheric pressure photoionization atmospheric-pressure solids analysis probe blackbody infrared radiative dissociation centi, 10-2 collision-activated dissociation capillary electrophoresis continuous flow continuous flow fast atom bombardment chemical ionization collision-induced dissociation continuous wave capillary zone electrophoresis dalton desorption atmospheric pressure chemical ionization direct analysis in real time direct current delayed extraction desorption electrospray ionization desorption/ionization on silicon drift tube ion mobility spectrometry electrochromatography electron capture dissociation electron ionization electrospray-assisted laser desorption/ionization electron multiplier electrospray ionization electron transfer dissociation electron volt femto, 1CT15 fast atom bombardment field asymmetric waveform ion mobility spectrometry field desorption field ionization Fourier transform Fourier transform ion cyclotron resonance... 

Harris, G.A. Graf, S. Knochenmuss, R. Fernandez, F.M., Couphng laser ablation/ desorption electrospray ionization to atmospheric pressure drift tube ion mobility spectrometry for the screening of antimalarial drug quality, Analyst 2012, 137, 3039-4044. 

FIGURE 8.2 Drift tube ion mobility spectrum of 2,4,6-trinitrotoluene (TNT) and 4,6-dinitro-o-cresol (4,6DNOC). (From Wu et al.. Construction and characterization of a high-flow, high-resolution ion mobility spectrometer for detection of explosives after personnel portal sampling, Talanta 2002,57,123-134. With permission.)... 

As described in previous chapters, there are many different types of ion mobility methods. These include drift tube ion mobility spectrometry (DTIMS), traveling wave ion mobility spectrometry (TW-IMS), differential mobility spectrometry (DMS), differential mobility analysis (DMA), and aspiration ion mobility spectrometry (alMS). All of these IMS methods have been interfaced to MSs. 

LOW-PRESSURE DRIFT TUBE ION MOBILITY SPECTROMETRY-MASS SPECTROMETRY... 

May, J.C. Russell, D.H., A mass-selective variable-temperature drift tube ion mobility-mass spectrometer for temperature dependent ion mobility studies, J. Am. Soc. Mass Spectrom. 2011, 22(7),1134-1145. 

Wildgoose, J.L. Giles, K. Pringle, S.D. Koeniger, S.L. Valentine, S.J. Bateman, R.H. Clemmer, D.E. A comparison of travelling wave and drift tube ion mobility separations. Proc. 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, May 28-June 1, 2006, ThP 64.AQ... 

FIGURE 20.6 Schematic of a typical drift tube-ion mobility spectrometry (DT-IMS). Source Borsdorf) H., Eiceman, G. A. (2006) Ion mobility spectrometry principles and applications. Applied Spectroscopy Reviews, 41(4), 323-375. 

In its simplest form, the drift-tube ion-mobility system measures how fast a given ion moves in a uniform electric field through a given atmosphere. Thus, an ion-mobility system separates ions by shape and charge. The flow drift technique can be apphed to determine quantities like ion mobility and diffusion coefficient, as these ate functions of the nonreactive attractive and repulsive ion-neutral interactions [129, 130]. Ion mobilities have been measured for a wide range of ions in several buffer gases (He, N2, Ar). With Ar as buffer gas, the mobility can be predicted with reasonable accuracy, whereas the measured mobility in He shows poor agreement with theoretical predictions [131]. 

Fjeldsted, J.C. and McLean, J.A. (2014) Conformational ordering of biomolecules in the gas phase Nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer. Anal. Chem. 86, 2107-2116. 

We thank Dr. Erin Shammel Baker for the information on absolute cross sections of angiotensin I 3-t, fibrinopeptide A 2+, fibrinopeptide A 3-I-, and neurotensin 3-i-measured using drift tube ion mobility-mass spectrometry with nitrogen as buffer gas. Our appreciation also goes to Prof. Ryan Julian for initial discussions on ion mobility measurements using a barrier voltage in an OTOF mass spectrometer. We also thank Dr. Melvin Park, Dr. Ruediger Frey, Dr. Annin Holle, Dr. Ian Sanders, and Dr. Michael Schubert for fruitful discussions. 

The back end mass analysis is performed with an orthogonally configured time-of-flight mass spectrometer (TOFMS) built in house. Coupling these two temporally dispersive types of analyses, drift tube ion mobility and TOFMS, results in a very powerful analytical configuration since for every analysis cycle, a complete... 

Kwasnik, M. Caramore, J. Fernandez, R M., Digitally-Multiplexed Nanoelectrospray Ionization Atmospheric Pressure Drift Tube Ion Mobility Spectrometry , Anal. Chem. 2009, 81,1587-1594. 

Ion mobility spectrometry is a rapid gas-phase separation technique that has commonly been nsed to separate small molecules such as drugs and explosives. " A drift tube ion mobility spectrometer (DUMS) consists of alternating condncting rings... 

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