Drift tube-ion mobility spectrometry

DGE a AC AMS APCI API AP-MALDI APPI ASAP BIRD c CAD CE CF CF-FAB Cl CID cw CZE Da DAPCI DART DC DE DESI DIOS DTIMS EC ECD El ELDI EM ESI ETD eV f FAB FAIMS FD FI FT FTICR two-dimensional gel electrophoresis atto, 10 18 alternating current accelerator mass spectrometry atmospheric pressure chemical ionization atmospheric pressure ionization atmospheric pressure matrix-assisted laser desorption/ionization atmospheric pressure photoionization atmospheric-pressure solids analysis probe blackbody infrared radiative dissociation centi, 10-2 collision-activated dissociation capillary electrophoresis continuous flow continuous flow fast atom bombardment chemical ionization collision-induced dissociation continuous wave capillary zone electrophoresis dalton desorption atmospheric pressure chemical ionization direct analysis in real time direct current delayed extraction desorption electrospray ionization desorption/ionization on silicon drift tube ion mobility spectrometry electrochromatography electron capture dissociation electron ionization electrospray-assisted laser desorption/ionization electron multiplier electrospray ionization electron transfer dissociation electron volt femto, 1CT15 fast atom bombardment field asymmetric waveform ion mobility spectrometry field desorption field ionization Fourier transform Fourier transform ion cyclotron resonance... 

Harris, G.A. Graf, S. Knochenmuss, R. Fernandez, F.M., Couphng laser ablation/ desorption electrospray ionization to atmospheric pressure drift tube ion mobility spectrometry for the screening of antimalarial drug quality, Analyst 2012, 137, 3039-4044. 

As described in previous chapters, there are many different types of ion mobility methods. These include drift tube ion mobility spectrometry (DTIMS), traveling wave ion mobility spectrometry (TW-IMS), differential mobility spectrometry (DMS), differential mobility analysis (DMA), and aspiration ion mobility spectrometry (alMS). All of these IMS methods have been interfaced to MSs. 

LOW-PRESSURE DRIFT TUBE ION MOBILITY SPECTROMETRY-MASS SPECTROMETRY... 

FIGURE 20.6 Schematic of a typical drift tube-ion mobility spectrometry (DT-IMS). Source Borsdorf) H., Eiceman, G. A. (2006) Ion mobility spectrometry principles and applications. Applied Spectroscopy Reviews, 41(4), 323-375. 

Kwasnik, M. Caramore, J. Fernandez, R M., Digitally-Multiplexed Nanoelectrospray Ionization Atmospheric Pressure Drift Tube Ion Mobility Spectrometry , Anal. Chem. 2009, 81,1587-1594. 

Wildgoose, J.L. Giles, K. Pringle, S.D. Koeniger, S.L. Valentine, S.J. Bateman, R.H. Clemmer, D.E. A comparison of travelling wave and drift tube ion mobility separations. Proc. 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, May 28-June 1, 2006, ThP 64.AQ... 

We thank Dr. Erin Shammel Baker for the information on absolute cross sections of angiotensin I 3-t, fibrinopeptide A 2+, fibrinopeptide A 3-I-, and neurotensin 3-i-measured using drift tube ion mobility-mass spectrometry with nitrogen as buffer gas. Our appreciation also goes to Prof. Ryan Julian for initial discussions on ion mobility measurements using a barrier voltage in an OTOF mass spectrometer. We also thank Dr. Melvin Park, Dr. Ruediger Frey, Dr. Annin Holle, Dr. Ian Sanders, and Dr. Michael Schubert for fruitful discussions. 

Ion mobility spectrometry is a rapid gas-phase separation technique that has commonly been nsed to separate small molecules such as drugs and explosives. " A drift tube ion mobility spectrometer (DUMS) consists of alternating condncting rings... 

Ion mobility spectrometry (IMS) [3,12] is the most widely used instrument for drug detection. The sample is heated to vaporize the analyte, which is then ionized by atmospheric (ambient) pressure chemical ionization (APCI) [3]. The resulting gas-phase ions travel through a drift tube and are separated by their distinct velocities (mobilities) in a weak electrostatic field. IMS instruments use ambient air or nitrogen as the carrier gas, making it particularly adaptable to field applications. 

The theory of operation of ion mobility spectrometry is that the velocity (V) of an ion down the drift tube is directly proportional to the applied electric held (E)41 49 K is commonly referred to as the mobility constant and can be used to correct for temperature and pressure. 

Fig. 6. Schematic of a differential mobility spectrometer showing the principles of ion separation in a differential mobility spectrometry (DMS) drift tube. Ion paths are governed by both the asymmetric electric field and field dependence of mobility for an ion. The inset displays the asymmetric waveform of separation electric field used in the DMS drift tube. The waveforms shown are theoretical (top part) and actual or experimental (bottom part) used in these experiments.

An important tool in the study of protein conformation and noncovalent protein complexes is the on-line combination of ion-mobility spectrometry (IMS) and MS. The IMS-MS instruments consists of an ESI source with related ion optics, a drift tube, and a mass spectrometer [75-76]. Quadrapole and TOF-MS instruments have been applied most frequently. In an IMS instrument, ions drift through a buffer gas under the iirfluence of a weak uniform electric field. The IMS separation of ions is based on differential mobility of ions related to shape and charge state. Within a particular charge state, compact ions show a higher mobility than more extended structures, because they experience fewer collisions. In this way, conformation differences between ions can be discovered. Compact ions have a smaller collision cross section. 

V/cm triangles, 275 V/cm stars, 325 V/cm and diamonds, 375 V/cm and (b) when was normalized to corresponding drift fields E. (From Tadjimukhamedov et al., A study of the performance of an ion shutter for drift tubes in atmospheric pressure ion mobility spectrometry computer models and experimental findings. Rev. Sci. Inst. 2009. With permission.)... 

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