Differential mobility analysis

Hogan, C.J., Jr. de la Mora, J.R, Ion mobility measurements of non-denatured 12-150 kda proteins and protein multimers by tandem differential mobility analysis-mass spectrometry (DMA-MS), J. Am. Soc. Mass Spectrom. 2011, 22,158-172. 

Bacher, G. Szymanski, W. Kaufman, S. Zollner, R Blass, D. Allmaier, G., Charge-reduced nanoelectrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses. J. Mass Spectrvm. 2001, 36(9), 1038-1052. 

While time-dispersive ion mobility devices of the type used for drift tube IMS require aperture grids prior to the Faraday plate to preserve the resolving power of the instrument, ion filters and scanning mobility spectrometry such as differential mobility spectrometry (DMS), field asymmetric IMS (FAIMS), differential mobility analysis (DMA), and aspiration IMS (alMS) do not require an aperture grid and can efficiently detect ions with a simple Faraday plate. In these devices, ions do not travel as a discrete swarm, and the exact arrival time of the ions is not critical. Figure 7.3 shows a schematic of a typical differential ion mobility spectrometer (DIMS) in... 

As described in previous chapters, there are many different types of ion mobility methods. These include drift tube ion mobility spectrometry (DTIMS), traveling wave ion mobility spectrometry (TW-IMS), differential mobility spectrometry (DMS), differential mobility analysis (DMA), and aspiration ion mobility spectrometry (alMS). All of these IMS methods have been interfaced to MSs. 

FIGURE 9.16 Sketch of a high-transmission ESI-DMA-MS interface. (From Fernandez de le Mora Ude, S. Thomson, B.A., The potential of differential mobility analysis coupled to MS for the study of very large singly and multiply charged proteins and protein complexes in the gas phase, Biotechnol. J. 2006, 1, 988-997. With permission.)... 

Eemandez de la Mora, J., de Juan, L., Eichler, T., RoseU, J., Differential mobility analysis of molecular ions and nanometer particles. TrAC 1998,17, 328. 

Fernandez De La Mora, J. Ude, S. Thomson B. A. The Potential of Differential Mobility Analysis Coupled to MS for the Study of Very Large Singly and Multiply Charged Proteins and Protein Complexes in the Gas Phase. Biotechnol. J. 2006,1, 988-997. 

C. J. Hogan, E. Folta-Stogniev, B. Ruotolo, J. Fernandez de la Mora, IMS-MS study of native aggregates, from insulin to GroEL. To be submitted to Anal. Chem. 2009 Hogan, C., Ruotolo, B., Robinson, C., Fernandez de la Mora, J. Tandem differential mobility analysis-mass spectrometry of the GroEL complex Structure compaction in the gas phase and inelastic air-protein interaction, Submitted to J. Phys. Chem. B, 2010. 

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