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Doxorubicin release

Figure 1 Facing page) (A) Mechanism of remote loading of doxorubicin by transmembrane ammonium sulfate gradient. (B) Collapse of transmembrane ammonium ion gradient in SSL by nonactine induces doxorubicin release. (C) Collapse of transmembrane proton gradient in SSL by nigericin induces collapse of transmembrane ammonium ion gradient followed by release of DOX. Abbreviations. DOX, doxorubicin SSL, sterically stabilized liposome. Figure 1 Facing page) (A) Mechanism of remote loading of doxorubicin by transmembrane ammonium sulfate gradient. (B) Collapse of transmembrane ammonium ion gradient in SSL by nonactine induces doxorubicin release. (C) Collapse of transmembrane proton gradient in SSL by nigericin induces collapse of transmembrane ammonium ion gradient followed by release of DOX. Abbreviations. DOX, doxorubicin SSL, sterically stabilized liposome.
Hickey, A.J. Tian, Y. Parasrampuria, D. Kanke, M. Biliary elimination of bromsulfthalein, phenolphthalein, and doxorubicin released from microspheres following intravenous administration. Biopharm. Drug Disposition 1993, 14 (2), 181-186. [Pg.2326]

Ning S, Macleod K, Abra RM, Huang AH, Hahn GM. Hyperthermia induces doxorubicin release from long-circulating liposomes and enhances their anti-tumor efficacy. Int J Radiat Oncol Biol Phys 1994 29 827-834. [Pg.239]

A. Kakinoki, Y. Kaneo, Y. Ikeda, T. Tanaka and K. Fujita, Synthesis of poly(vinyl alcohol)-doxorubidn conjugates containing cis-aconityl acid-cleavable bond and its isomer dependent doxorubicin release, Biol. Phurm. Bull., 31,103-110 (2008). [Pg.63]

B. ftfliovd, J. Strohalm, O. Hovorka, O. Subr, T. Etrych, P. Chytil, R. Pola, D. Plocovd, J. Boucek and K. Ulbrich, Doxorubicin release is not a prerequisite for the in vitro cytotoxicity of HPMA-based pharmaceuticals in vitro effect of extra drug-free GlyPheLeuGly sequences, /. Control. Release, 127,110-120 (2008). [Pg.71]

Bruld S, Levy M, Wilhelm C, Letoumeur D, Gazeau F, Menager C, Visage C. Doxorubicin release triggered by alginate embedded magnetic nanoheaters a combined therapy. Adv Mater. 2011 23 787-90. [Pg.145]

J.S. Bcisuki, H.T. Duong, A. MacmiUcin, R.B. Erlich, L. Esser, M.C. Akerfeldt, R.M. Whan, M. Kavallaris, C. Boyer, and T.P. Davis, Using fluorescence lifetime imaging microscopy to monitor theranostic nanoparticle uptake and intracellular doxorubicin release, ACS Nano, 7,10175-89,2013. [Pg.575]

Conjugation of a 2-nitroimidazole derivative to carboxymethyl dextran allowed doxorubicin-loading with hypoxia-induced cellular uptake and cytotoxicity in vitro [110]. The dextran group for stability in the circulation and primary tumor accumulation was combined with conversion from a hydrophobic 2-nitroimidazole to a hydrophilic 2-aminoimidazole under hypoxia to promote doxorubicin release in tumor environment. This system showed a 4-fold doxorubicin accumulation in tumor over liver, lung, spleen, kidney, and heart 24 h after systemic injection and enhanced anticancer activity in vivo over free drug. [Pg.321]

PDTC, doxorubicin Doxorubicin released from pH-sensitive folate-chitosan micellar nanoparticle. The particle showed the ability for co-delivery of PDTC and doxorubicin in vitro [26]... [Pg.145]

Doxorubicin release-profile from the hexamethylene diisocyanate-Pluronic F127/ HA composite hydrogel was almost zero-order release during 28 days [73]. This system also showed antitumor efficacy and therapeutic effects in animal study. [Pg.25]

A. (1990b). Effect of lipid composition on the in vivo integrity of doxorubicin-containing liposomes. Two pathways for sustained release of doxorubicin. Submitted. [Pg.335]

Dreher MR, Raucher D, Balu N et al (2003) Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. J Control Release 91 31 3... [Pg.166]

HS Yoo, JE Oh, KH Lee, TG Park. Biodegradable nanoparticles containing doxorubicin-PLGA conjugate for sustained release. Pharm Res 16(7) 1114-1118, 1999. [Pg.289]

Kataoka K, Matsumoto T, Yokoyama M et al (2000) Doxorubicin-loaded poly(ethylene glycol)-poly(P-benzyl-L-aspartate) copolymer micelles their pharmaceutical characteristics and biological significance. J Control Release 64 143-153... [Pg.58]

Veronese FM, Schiavon O, Pasut G, Mendichi R, Andersson L, Tsirk A, Ford J, Wu G, Kneller S, Davies J, Duncan R (2005) PEG-doxorubicin conjugates influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity. Bioconjug Chem 16 775-784... [Pg.137]

Brigger I, Morizet J, Laudani L, Aubert G, Appel M, Velasco V, Terrier-Lacombe MJ, Desmaele D, d Angelo J, Couvreur P, Vassal G (2004) Negative preclinical results with stealth) (R)) nano-spheres-encapsulated Doxorubicin in an orthotopic murine brain tumor model. Journal of Controlled Release 100 29 10. [Pg.258]

G. M. Dubowchik, R. A. Firestone, Cathepsin B-Sensitive Dipeptide Prodrugs. 1. A Model Study of Structural Requirements for Efficient Release of Doxorubicin , Bioorg. Med. Chem. Lett. 1998, 8, 3341-3346. [Pg.371]

Horowitz AT, Barenholz Y, Gabizon AA. In vitro cytotoxicity of liposome-encapsulated doxorubicin dependence on liposome composition and drug release. Biochim Biophys Acta 1992 1109 203-209. [Pg.23]

Li X, Cabral-Lilly D, Janoff AS, Perkins WR. Complexation of internalized doxorubicin into liber bundles affects its release rate from liposomes. J Liposome Res 2000 10 15. [Pg.49]

Chiu GN, Abraham SA, Ickenstein LM, et al. Encapsulation of doxorubicin into thermosensitive liposomes via complexation with the transition metal manganese. J Control Release 2005 104 271. [Pg.50]

See other pages where Doxorubicin release is mentioned: [Pg.33]    [Pg.1191]    [Pg.33]    [Pg.46]    [Pg.53]    [Pg.190]    [Pg.52]    [Pg.317]    [Pg.52]    [Pg.149]    [Pg.595]    [Pg.799]    [Pg.4]    [Pg.124]    [Pg.33]    [Pg.1191]    [Pg.33]    [Pg.46]    [Pg.53]    [Pg.190]    [Pg.52]    [Pg.317]    [Pg.52]    [Pg.149]    [Pg.595]    [Pg.799]    [Pg.4]    [Pg.124]    [Pg.161]    [Pg.243]    [Pg.250]    [Pg.119]    [Pg.156]    [Pg.122]    [Pg.1490]    [Pg.519]    [Pg.522]    [Pg.575]    [Pg.752]    [Pg.387]    [Pg.42]    [Pg.220]    [Pg.684]    [Pg.17]    [Pg.161]   
See also in sourсe #XX -- [ Pg.268 ]



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