Dose evaluation

Cohen, G. and F.A. DiBianca, The use of contrast-detail-dose evaluation of image quality in a computed tomographic scanner. Journal of Computer Assisted Tomography, 1979. 3(2) p. 189-195. 

Loading dose - 20 mg IV over 30 min x one dose. Evaluate response and need for additional doses or continuous IV infusion... 

Increasing the dose Evaluate each new dose used over several episodes of breakthrough cancer pain (generally 1 to 2 days) to determine whether it provides adequate efficacy with acceptable side effects. 

Anastrozole (2) and letrozole (3) are type II aromatase inhibitors. They competitively inhibit the conversion of androgens to estrogens. They are both potent and selective aromatase inhibitors. Anastrozole is the most extensively investigated third-generation aromatase inhibitor. It is very potent, with a daily dose of a mere 1 mg. Its safety profile is well developed all doses evaluated up to 10 mg were well tolerated and no serious adverse events were attributed to it. No clinical or laboratory evidence of adrenal insufficiency was observed. 

SC 64-18 Risks from Space Applications of Plutonium SC 64-19 Historical Dose Evaluation SC 64-20 Contaminated Soil... 

Wong YN, Simcoe D, Hartman LN, Laughton WB, King SP, McCormick GC, Grebow PE. A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. J Clin Pharmacol 1999 39 30-40. 

SDSS/MDSS Efficacious dose evaluation study, i.e. 

Conduct multiple-dose evaluation of drug candidate efficacy in patients with disease indication. 

Improving pharmacy services Decentralized pharmacy services Patient education programs Cost-justifying clinical pharmacy services Missing dose evaluation... 

LUDEP (LUng Dose Evaluation Program) was developed concurrently with the new ICRP respiratory tract model. LUDEP was designed principally for two applications ... 

Applies to gamma rays or X-rays delivered to the indicated organ or tissue in less than 1 h. For 50-100cm area of skin and the dose evaluated at a depth of 0.1 mm. 

In a single-dose evaluation, 6 jig./kg. of ICI 50,123 was equivalent to (XS /l S of histamine acid phosphate.° Ho synthetic derivatives of gastrin, other than those already reviewed,9 have been described. 

IAEA, Population Dose Evaluation and Standards for Man and his Environment, Vienna, 1974. 

COOH (DOCO 27), 4-isopropyl (DOIP 12), and 4-chloro (DOC 6) derivatives of 2,5-DMA in DOM-trained animals. (Drugs were administered via the ip route 15 min prior to testing figure may not show all doses evaluated.)... 

Haskell, C.F., D.O. Kennedy, K.A. Wesnes, A.L. Milne, and A.B. Scholey. 2007. A double-blind, placebobehavioural effects of guarana in humans. /. Psychopharmacol. 21(l) 65-70. 

As elsewhere in this book, here only simple methods and orders of magnitude are listed which can be useful for quick dose evaluations for preliminary decisions more precise methods are described in the references and in the abundant literature in the field. 

In case (1) in gamma facilities the dose vs. irradiation time (in plants with no product transport system) or the dwell time (in plants with product transport system) can be measured by using different reference standard, transfer standard, or routine dosimeters. In EB facilities, the dose vs. conveyor speed relationship can be measured mainly with process calorimeters, but other dosimetry systems with quick dose evaluation capabilities after irradiation can also be used for this purpose. 

Administration of 2 -deoxycoformycin (Warner-Lambert Pharmaceuticals) to malaria infected rhesus monkeys was by a single 250 ug/ kg (i.v.) dose. Evaluation of the drugs effect on parasitemia and parasite morphology was by microscopic examination of Giemsa stained thin blood smears. 

C-arm CT systems with automatic exposure control (AEG) adjust X-ray exposure parameters such that the detector entrance dose remains constant. Detector entrance dose is the X-ray dose measured behind the antiscatter grid. System dose is the detector entrance dose evaluated at a reference detector zoom format. System dose is an important set-up parameter for C-arm CT imaging protocols on Artis zee systems (Siemens AG, Healthcare Sector, Forchheim, Germany). Due to internal adjustments, the detector entrance dose for C-arm CT is about half the system dose. 

Stamm G, Nagel HD (2002) CT-Expo - ein neirartiges Pro-gramm zur Dosisevalimtion in der CT [CT-Expo - a novel program for dose evaluation in CT]. Rofo 174 1570-1576... 

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