Dopamine anterior cingulate cortex

FTND Fagerstrom test for nicotine dependence, M mean NR not reported NA not applicable ACC anterior cingulate cortex PCC posterior cingulate cortex OFC orbitofrontal cortex SFG superior frontal gyrus DLPFC dorsal lateral prefrontal cortex DRD4L dopamine receptor 4 variable number tandem repeat Data shown for FTND and pack-years are means for the smokers Pack-years = packs of cigarettes smoked per day x number of years smoked... 

Suhara T, Okubo Y, Yasuno F, Sudo Y, Inoue M, et al. 2002. Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia. Arch Gen Psychiatry 59 25-30. 

Fig. 7. Anatomical organization of dopamine Di mRNA expression in the adult human brain (whole hemisphere horizontal images) at a dorsal (A) and ventral (B) level. Notice strong cortical expression of this dopamine receptor subtype in addition to the intense expression levels in the striatum (CN, Pu and NAc). Adapted from Hurd et al. (2001). aCg, anterior cingulate Amy, amygdala Cb, cerebellum cc, corpus callosum CN, caudate nucleus Cun, cuneus F, frontal lobe Hip, hippocampus hyp, hypothalamus I, insular cortex mPFC, medial prefrontal cortex mm, medial mammillary nucleus NAc, nucleus accumbens O, occipital lobe Phg, parahippocampal gyrus Pu, putamen SN, substantia nigra T, temporal lobe U, uncal gyrus.

Fig. 10. Anatomical organization of the dopamine D5 mRNA in the adult human brain (coronal images). The images represent the D5 expression pattern in a whole coronal hemisphere section at a mid-striatal level (A) and a coronal section at the postcommissural striatal level (B). Note the intense D5 mRNA expression primarily in the cerebral cortex (e.g. mOPFC and SF). Moderate to strong labeling is also apparent in the claustrum and anterior amygdala nucleus. aCg, anterior cingulate AAA, anterior amygdala nucleus B, magnocellular basal forebrain complex cc, corpus callosum Cl, claustrum CN, caudate nucleus F, frontal hyp, hypothalamus I, insular cortex OPFC, orbital prefrontal cortex NAc, nucleus accumbens Pu, putamen SF, superior frontal T, temporal cortex.

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