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Discovery Trends

There is always an additional burden on scientists to assure that in their pursuit of novelty in creating a value for their company, they must review the vast databases of patents involved. It is for this reason that in describing the overall drug development scene, an in-depth discussion of what constitutes intellectual property, how to evaluate it, and search for new ideas is presented in a separate chapter. [Pg.1]

Pommier, Y., and Cherfils, J. (2005). Interfacial inhibition of macromolecular interactions Nature s paradigm for drag discovery. Trend. Pharmacol. Sci. 26 138—145. [Pg.172]

Pommier Y, Cherfils J (2005) Interfacial protein inhibition a nature s paradigm for drug discovery. Trends Pharmacol Sci 28 136 4-5... [Pg.317]

Stadel, J. M., Wilson, S., and Bergsma, D. J., Orphan G-protein-coupled receptors a neglected opportunity for pioneer drug discovery, Trends Pharmacol. Sci., 18(11), 430 437, 1997. [Pg.108]

Terstappen, G. and Reggiani, A. 2001. In silico research in drug discovery. Trends in Pharmacological Sciences 22(1), 23-26. [Pg.104]

Dean, P.M., et al., "Industrial-Scale, Genomics-Based Drug Design and Discovery," Trends Biotechnol., 19, 288-292 (2001). [Pg.55]

Howard, A. D., McAllister, G., Feighner, S. D., et al. (2001) Orphan G-protein-coupled receptors and natural ligand discovery. Trends Pharmacol. Sci. 22, 132-140. [Pg.98]

Harvey AL. (1999) Medicines from nature Are natural products still relevant to drug discovery Trends Pharmacol Sci 20 196-198. [Pg.118]

Lam KS. (2007) New aspects of natural products in drug discovery. Trends in Microbiol 15 279-289. [Pg.120]

Tulp M, Bohlin L. Functional versus chemical diversity is biodiversity important for drug discovery Trends Pharmacol Set 2002 23 225S31. [Pg.75]

Michels PC, Khmelnitsky YL, Dordick JS, et al. Combinatorial biocatalysis a natural approach to drug discovery. Trends Biotechnol 1998 16 210-15. [Pg.77]

Scicinski, J. (1995). Chemical libraries in drug discovery. Trends Biotechnol 13, 246-247. [Pg.91]

Terstappen, G. Reggiani, A. (2001). In silico research in drug discovery. Trends Pharmacol. Sci. 22(1), 23-26. Wamg, J. Hewick, R. (1999). Proteomics in drug discovery. Drug Discovery Today 4(3), 129-133. [Pg.91]

Galandrin S, Oligny-Longpre G, Bouvier M The evasive nature of drug efficacy Implications for drug discovery. Trends Pharmacol Sci 2007 28 423. [PMID 17659355]... [Pg.57]

AccessMedicine Print Chapter 16. Histamine, Serotonin, the Ergot Alkaloids discovery. Trend Pharmacol Sci 2006 27 92. [PMID 16406086]... [Pg.371]

Bertorelli, R., Calo, G., Ongini, E., Regoli, D. Nociceptin/orpanin FQ and its receptor a potential target for drug discovery Trends Pharmacol. Sci. 2000, 21, 233-234. [Pg.147]

MH Pausch. G protein-coupled receptors in Saccharomyces cerevisiae. high-throughput screening assays for drug discovery. Trends Biotechnol 15 487-494, 1997. [Pg.339]

Gelboin HV, Krausz KW, Gonzalez FJ, et al. Inhibitory monoclonal antibodies to human cytochrome P450 enzymes a new avenue for drug discovery. Trends Pharmacol Sci 1999 20 432-438. [Pg.356]

Bevan P, Ryder H, Shaw I (1995) Identifying small-molecule lead compounds the screening approach to drug discovery. Trends Biotechnol 13 115-121... [Pg.28]

Ekins S, Freundlich JS, Choi I (2011) Computational databases, pathway and chem-informatics tools for tuberculosis drug discovery. Trends Microbiol 19 65-74... [Pg.260]

Reed JC. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med 2001 7 314-319. [Pg.41]

Giuliano, K.A., and Taylor, D.L. 1998. Fluorescent-protein biosensors new tools for drug discovery. Trends Biotechnol. 16, 135-140. [Pg.155]

Weissman KJ (2007) Mutasynthesis - Uniting Chemistry and Genetics for Drug Discovery. Trends Biotechnol 25 139... [Pg.236]

Stables, J. Green, A. Marshall, F. et al. A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. Anal. Biochem. 1997, 252, 115-126. Milligan, G. Rees, S. Chimaeric G alpha proteins their potential use in drug discovery. Trends Pharmacol. Sci. [Pg.3127]

McFarland EW, Weinberg WH. Combinatorial approaches to material discovery. Trends Biotechnol 1999 17 107-15. [Pg.93]

Bond, R. A., Ijzerman, A. P. Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends Pharmacol. Sci. 2006, 27, 92—96. [Pg.104]

See other pages where Discovery Trends is mentioned: [Pg.242]    [Pg.120]    [Pg.661]    [Pg.161]    [Pg.119]    [Pg.184]    [Pg.1]    [Pg.3]    [Pg.5]    [Pg.7]    [Pg.11]    [Pg.13]    [Pg.15]   


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