Drug discovery trends

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Stadel, J. M., Wilson, S., and Bergsma, D. J., Orphan G-protein-coupled receptors a neglected opportunity for pioneer drug discovery, Trends Pharmacol. Sci., 18(11), 430 437, 1997. 

Terstappen, G. and Reggiani, A. 2001. In silico research in drug discovery. Trends in Pharmacological Sciences 22(1), 23-26. 

Harvey AL. (1999) Medicines from nature Are natural products still relevant to drug discovery Trends Pharmacol Sci 20 196-198. 

Lam KS. (2007) New aspects of natural products in drug discovery. Trends in Microbiol 15 279-289. 

Tulp M, Bohlin L. Functional versus chemical diversity is biodiversity important for drug discovery Trends Pharmacol Set 2002 23 225S31. 

Michels PC, Khmelnitsky YL, Dordick JS, et al. Combinatorial biocatalysis a natural approach to drug discovery. Trends Biotechnol 1998 16 210-15. 

Scicinski, J. (1995). Chemical libraries in drug discovery. Trends Biotechnol 13, 246-247. 

Terstappen, G. Reggiani, A. (2001). In silico research in drug discovery. Trends Pharmacol. Sci. 22(1), 23-26. Wamg, J. Hewick, R. (1999). Proteomics in drug discovery. Drug Discovery Today 4(3), 129-133. 

Galandrin S, Oligny-Longpre G, Bouvier M The evasive nature of drug efficacy Implications for drug discovery. Trends Pharmacol Sci 2007 28 423. [PMID 17659355]... 

Bertorelli, R., Calo, G., Ongini, E., Regoli, D. Nociceptin/orpanin FQ and its receptor a potential target for drug discovery Trends Pharmacol. Sci. 2000, 21, 233-234. 

MH Pausch. G protein-coupled receptors in Saccharomyces cerevisiae. high-throughput screening assays for drug discovery. Trends Biotechnol 15 487-494, 1997. 

Gelboin HV, Krausz KW, Gonzalez FJ, et al. Inhibitory monoclonal antibodies to human cytochrome P450 enzymes a new avenue for drug discovery. Trends Pharmacol Sci 1999 20 432-438. 

Bevan P, Ryder H, Shaw I (1995) Identifying small-molecule lead compounds the screening approach to drug discovery. Trends Biotechnol 13 115-121... 

Ekins S, Freundlich JS, Choi I (2011) Computational databases, pathway and chem-informatics tools for tuberculosis drug discovery. Trends Microbiol 19 65-74... 

Reed JC. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med 2001 7 314-319. 

Giuliano, K.A., and Taylor, D.L. 1998. Fluorescent-protein biosensors new tools for drug discovery. Trends Biotechnol. 16, 135-140. 

Weissman KJ (2007) Mutasynthesis - Uniting Chemistry and Genetics for Drug Discovery. Trends Biotechnol 25 139... 

Stables, J. Green, A. Marshall, F. et al. A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. Anal. Biochem. 1997, 252, 115-126. Milligan, G. Rees, S. Chimaeric G alpha proteins their potential use in drug discovery. Trends Pharmacol. Sci. 

Pommier, Y., and Cherfils, J. (2005). Interfacial inhibition of macro-molecular interactions Nature s paradigm for drug discovery. Trend. Pharmacol. Sci. 26 138-145. 

Bond, R. A., Ijzerman, A. P. Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends Pharmacol. Sci. 2006, 27, 92—96. 

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