3.4- Diphenyl- -Hydrochlorid

Chemical Name 2-Piperidinemethanol, a,a-diphenyl-, hydrochloride Common Name Pipradrol hydrochloride Structural Formula ... 

A portion of the monophenylurea then reacts with the aniline (formed by the hydrolysis of the aniline hydrochloride or cyanate) to give diphenyl-urea and ammonia, a reaction which probably proceeds through the... 

Dissolve 12 g. of aniline hydrochloride and 6 g. of urea in 50 ml. of warm water, and then filter the solution through a fluted filter to remove any suspended impurities which may have been introduced with the aniline hydrochloride. Transfer the clear filtrate to a 200 ml. conical flask, fit the latter with a reflux water-condenser, and boil the solution gently over a gauze for about hours. Crystals of diphenylurea usually start to separate after about 30-40 minutes boiling. Occasionally however, the solution becomes supersaturated with the diphenylurea and therefore remains clear in this case, if the solution is vigorously shaken after about 40 minutes heating, a sudden separation of the crystalline diphenyl compound will usually occur. The further deposition of the crystals during the re-... 

Diphenyl amine [122-39-4] is produced by heating aniline with aniline hydrochloride at 290°C and 2 MPa (21 atm) in an autoclave (15). 

The treatment of 3-acylisoxazoles (438) with hydroxylamine hydrochloride gives furazan ketones (439). On the other hand, furazan ketones (439) rearrange to 3-acylisoxazoles (438) with a loss of hydroxylamine under the influence of a mineral acid. Thus, by refluxing phenacylphenylfurazan with concentrated alcoholic hydrogen chloride, 3-benzoyl-5-phenyl-isoxazole is formed similarly, phenyl(phenacylphenyl)furazan gives 3-benzoyl-3,5-diphenyl-isoxazole (62HC(17)1, p. 35). 

A mixture of 14 g (0.05 mol) of a A-diphenyl-7-dlmethylaminovaleronitrile, 16 g (0.2 mol) of sodium acetate, 14 g (0.2 mol) of hydroxylamine hydrochloride and 75 ml of ethyl alcohol was refluxed IB hours. The mixture was cooled, poured Into water and neutralized with ammonium hydroxide. The heavy white precipitate solidified on standing. The material was filtered and recrystallized from isopropanol. After three recrystallizations the aminopentamide product melted at 177° to 179°C. 

The mixture is taken up with water and the base is extracted from the toluene with dilute hydrochloric acid. The hydrochloric solution is rendered alkaline with caustic soda, the base is separated with ether, dried, and after distillation of the ether fractionated in vacuo, BP at 0.05 mm Hg, 150° to 153°C. The basic ether is then dissolved in dry ether, and ether saturated with dry hydrogen chloride is added dropwise with stirring. An excess of hydrogen chloride must be avoided as it may produce decomposition to the corresponding diphenyl ethylene. The ether-moist hydrochloride is preferably dried at once in vacuo and subsequently reprecipitated from acetone-ether and then again dried in vacuo over phosphorus pentoxide. Hydrochloride, MP 12B°C. 

A mixture of 23 parts of the ethyl ester of 4 phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-bromobutyronitrile in 19 parts of xylene is heated for 24 hours at 100°-120°C and then cooled and filtered to remove the precipitate of the hydrobromide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2 diphenyl-4-(4 -carboxy-4 -phenyl-1 -piperidino) butyronitrile thus obtained melts at about 220.5-222°C. See Meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester. 

Chemical Name 1ethyl-4-(2-morpholinoethyl)-3,3 diphenyl-2 pyrrolidinone hydrochloride monohydrate... 

C) Preparation of Doxapram Hydrochloride [3,3-Diphenyl-1-Ethyl-4-(2-Morpholino-Ethylj-2-Pyrrolidinone Hydrochloride Monohydrate] A solution of 25 grams (0.076 mol) of 4-(2-chloroethyl)-3,3-diphenyl-1-ethyl-2-pyrrolidinone and 13.3 grams (0.153 mol) of morpholine in 500 ml of absolute ethanol was heated at 95°-120°C for 21 hours in a closed system and concentrated in vacuo. The residue was dissolved in 3(X) ml of two normal hydrochloric acid and extracted with 150 ml of ethyl acetate. A solid crystallized (13 g) during the extraction and was removed by filtration. MP 217°-219°C. The acid extracts were made basic with sodium hydroxide and extracted with ether, and the ether solution was concentrated in vacuo and the residue was suspended in six normal hydrochloric acid. Additional crystalline product formed and was recrystallized from two normal hydrochloric acid. Yield, 10 grams MP 217°-219°C. Total yield, 23 grams (70%). 

Chemical Name 7-phenyl-N-( TphenylethyDbenzenepropanamine hydrochloride Common Name N-(1-phenylethyl)-3,3-diphenyl-propylamine... 

Chemical Name 6-dimethylamino-4,4-diphenyl-3-heptanone hydrochloride Common Name Amidone hydrochloride Structural Formula r a. nicho,... 

Diphenylacetonitrile is condensed with 2dimethyl-amino)-2,2-diphenyl valeronitrile. It is then reacted with ethyl magnesium bromide and then hydrolyzed using HCl to give methadone hydrochloride. 

To make the hydrochloride salt, the bisacetamide or, by another name, 1,11-diphenyl-2,2,3,9,10,10-hexamethyl-4 3hydroxy ethyl )-3,6,9-triazaundecane is dissolved In n-butanol. The solution is chilled and then dry hydrogen chloride gas is passed into the solution causing an oil to separate. To the heavy oil ether is added and then stirred causing crystallization to occur. MP146°Cto 147°C. Analysis for nitrogen calc. 8.3%, found 8.2%. 

Chemical Name 5,5-diphenyl-2-[2-(1-piperidinyl)ethyl]-1,3-dioxolan-4-one hydrochloride Common Nama —... 

Dry hydrogen chloride gas was passed into the ether solution until precipitation was completed. The solid was removed by filtration and was recrystallized from a mixture of methanol and ethyl acetate. The a-dl-1,2-diphenyl-2-hydroxy-3-methyl-4-dimethylamino-butane hydrochloride thus obtained melted at about 231° to 232°C. 

A mixture of 50 grams of a-dl-1,2-diphenyl-2-hydroxy-3-methyl-4-dimethylaminobutane hydrochloride, 50 grams of propionic anhydride and 50 cc of pyridine was refluxed for about 5 hours. The reaction mixture was cooled to 50°C and ethyl ether was added to the point of incipient precipitation. The hydrochloride salt of 0 -dl-l,2-diphenyl-2-propion-oxy-3-methyl-4-dimethylamlnobutane formed in the reaction precipitated upon cooling and was removed by filtration and washed with anhydrous ether. On recrystallization from a mixture of methanol and ethyl acetate, a-dl-l, 2-diphenyl-2-propionoxy-3-methyl-4-dimethyl amlnobutane hydrochloride melted at 170°-171°C. 

C ( propyl) N phenylmtrone to N phenylmaleimide, 46, 96 semicarbazide hydrochloride to ami noacetone hydiochlonde, 46,1 tetraphenylcyclopentadienone to diphenyl acetylene, 46, 44 Alcohols, synthesis of equatorial, 47, 19 Aldehydes, aromatic, synthesis of, 47, 1 /3-chloro a,0 unsaturated, from ke tones and dimethylformamide-phosphorus oxy chloride, 46, 20 from alky 1 halides, 47, 97 from oxidation of alcohols with dimethyl sulfoxide, dicyclohexyl carbodumide, and pyndimum tnfluoroacetate, 47, 27 Alkylation, of 2 carbomethoxycyclo pentanone with benzyl chloride 45,7... 

Athyl-benzyl-amin — Athyl-(2-phenyl-dthyl)-amin —> Athyl-(2,2-diphenyl-dthyl)-amin — Athyl-(2,2-dimelhyl-propyl)-amin-Hydrochlorid... 

The value of using the preformed HHT with diphenyl phosphite in this procedure was readily apparent from the nearly quantitative conversion to glyphosate observed from 25. A much lower yield (38%) of glyphosate was obtained after hydrolysis when the same components (ethyl glycinate hydrochloride and formaldehyde) were mixed and heated with neat triphenyl phosphite to give triester 30 (43). 

Whilst anhydrous hydrazine is reported124) to give products of nucleophilic ring opening and cyclization (7 62/7 63) with diphenyl cyclopropenone, hydrazine hydrochloride yielded the azine 16112s ... 

Ethylamine, 2-chloro-N,N-dimethyl-, HYDROCHLORIDE, 31, 37 N-methyl-1,2-diphenyl-, 34, 64 N-Ethylaniline, 36, 22 Ethyl benzalmalonate, 37, 5 Ethyl benzoylacetate, 32, 85 37, 3 Ethyl benzoylacetate, 37, 32 Ethyl N-benzylcarbamate, 35, 91 Ethyl 3-benzyl-2-cyano-3-methylpenta-noate, 35, 7... 

Interaction of iV-pentafluorophenylcarbonimidoyl dichloride with benzonitrile and aluminium trichloride leads to l-pentafluorophenyl-4,6-diphenyl-13 -triazin-2-one along with urea derivatives . Reaction of perfluoro-5-azanon-4-ene with a range of bidentate nitrogen nucleophiles (urea, substituted amidine hydrochlorides and guanidine), in the presence of triethylamine or potassium hydroxide, effectively provides fluorinated 1,3,5-triazines 16-19 <00JFC(103)105>. 

A sample of dobutamine hydrochloride containing at least 2 mg of chlorine is ignited in a Schoniger flask containing 20 ml of water. Three drops of diphenyl carbazone (5 mg/ml) in methanol are added to the solution of the completely burned sample. Mercuric nitrate, 0.5 N, is then used to titrate this solution to the first sign of rose color, using a 1 ml microburette ... 

Several routes have been reported for the synthesis of aromatic poly(azole)s such as poly(benzimidazole), poly(benzoaxazole), and poly(benzthiazole) melt polycondensation of dicarboxylic acid diphenyl esters with tetramines21 and high-temperature solution polycondensation of dicarboxylic acids or their derivatives with tetramine hydrochlorides in PPA.22 PPA acts as condensing agent and solvent. Ueda etal.23 developed a modified method for the synthesis ofpolyazoles with the use of PPM A. 

Diphenyl-i-butene-i,4-dione, 29 Diphenylhydrazine, 15 Diphenylhydrazine hydrochloride, 15 Diphenylketene, 47 i,3-Diphenyl-i,3-propanedione, 32 Dodecanol, 50... 

PlCOLINIC ACID HYDROCHLORIDE, 79 Potassium acetate, 55 Potassium amide, 91 Potassium bromide, 81, 101 Potassium carbonate, 21 Potassium cyanide, 38, 44 Potassium permanganate, 79 Pressure reaction, 40, 81, ior i,3-Propanedione, i,3-diphenyl-, 32 Propionic acid, /3-3-acenaphthenyl-... 

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