7,12-Dimethylbenzanthracene DMBA

Hart, L.J. et al., Subacute immunotoxic effects of the polycyclic aromatic hydrocarbon 7,12-dimethylbenzanthracene (DMBA) on spleen and pronephros leukocytic cell counts and phagocytic cell activity in tilapia, Oreochromis niloticus, Aquat. Toxicol., 41, 17, 1998. 

An unspecified PBB mixture (purity not reported) was not tumorigenic when applied to the shaved dorsal skin of female CD-I mice at a dose of 3.3 mg/kg twice weekly for 30 weeks no tissues other than skin were examined (Berry et al. 1978, 1979). This same treatment did not promote the development of skin tumors in mice pretreated with a single application of a tumor initiator, dimethylbenzanthracene (DMBA),... 

Among the chemical carcinogens, dimethylbenzanthracene (DMBA) is one that is widely used in experimental studies. A large body of literature gathered over several decades exists from studies of DMBA carcinogenicity in fish (see review 13). 

Robinson, S.P., Mauel, D.A. and Jordan, V.C. (1988) Antitumor actions of toremifene in the 7,12-dimethylbenzanthracene (DMBA)-induced rat mammary tumor model. European Journal of Cancer and Clinical Oncology, 24, 1817-1821. 

JP-8 has not been tested for tumor-initiating or -promoting activity. Jet fuel A has been tested for tumor promoting activity in the CD-I mouse model of skin tumors initiated by dimethylbenzanthracene (DMBA) (Nessel et al. 1999). Other MDFs have been tested for tumor-promoting activity in the same model system. In addition, hydrodesulfurized kerosene, hydrodesulfur-ized middle distillates, and lightly refined paraffinic oil have been tested for initiating activity with the model. Those studies are briefly described below. 

Two stage mouse skin carcinogenesis initiated with dimethylbenzanthracene (DMBA) and promoted with TPA Topical application of astilbin or (+)-taxifolin exhibited significant inhibitory effect. 

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