Diclofenac Aspirin

Known hypersensitivity to diclofenac, aspirin, or other NSAIDs. 

Less severe pain states (e.g., arthritis, menstruation, headache, minor surgery) are commonly treated with nonselective NSADDs (e.g., aspirin, ibuprofen, indo-methacin, diclofenac). NSAIDs are mostly used orally. 

NSAIDs are of diverse chemical structures salicylates (aspirin, sulphasalazine), indole acetic acids (indomethacin, etodolac), heteroaryl acetic acids (diclofenac), arylpropionic acids (ibuprofen, naproxen), anthranilic acids (mefenamic acid) and enolic acids (piroxicam, meloxicam). 

Neural networks have also been used in Slovenia, to model the release characteristics of diclofenac [52] in China, to study release of nifedipine and nomodipine [53] and in Yugoslavia to model the release of aspirin [54], More recently, work in this area has been extended to model osmotic pumps in China [55] and enteric coated tablets in Ireland [56],... 

Ipratropium metered dose inhaler (MDI) 2 puffs every 6 hours Albuterol MDI 2 puffs every 4 hours as needed Prednisone 10 mg daily Diclofenac 75 mg two times a day Aspirin 81 mg daily... 

Aspirin Ibuprofen Naproxen sodium Diclofenac potassium Ergotamine tartrate... 

Voltarol is a brand-name preparation for diclofenac (NSAID) and modified-release tablets are available in 75 mg and 100 mg strength. Nu-seals is a proprietary preparation of enteric-coated aspirin 75 mg. Fentanyl, co-codamol and Suboxone (buprenorphine and naloxone) consist of opioid drugs. 

Diclofenac possesses all of the properties unique to the series of propionic acid drugs, yet in terms of anti-inflammatory and analgesic strength it exceeds that of aspirin, analgin, and ibnprofen. It is used in acnte rheumatism, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, and myalgia. It rarely causes side effects. The most common synonym is voltaren. 

Hypersensitivity to diclofenac or to misoprostol or other prostaglandins. Do not give to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. 

Many NSAIDs inhibit both COX-1 and COX-2. Most NSAIDs are mainly COX-1 selective (eg, aspirin, ketoprofen, indomethacin, piroxicam, sulindac). Others are considered slightly selective for COX-1 (eg, ibuprofen, naproxen, diclofenac) and others may be considered slightly selective for COX-2 (eg, etodolac. 

Some non-steroidal anti-inflammatory drugs (NSAIDs) were found to have the following capacity factors in a particular mobile on a reverse-phase column aspirin 0.4, naproxen 3.6, ibuprofen 14.5, diclofenac 10.4, paracetamol 0.2. Given that the column had a t of 2 min determine the retention times of the NSAIDs. 

Contraindications Hypersensitivity to aspirin, diclofenac, and other NSAlDs porphy-... 

Avoid alcohol and aspirin during diclofenac therapy because these substances increase the risk of G1 bleeding... 

Indomethacin and sulindac are slightly selective for COX-1. Meclofenamate and ibuprofen are approximately equipotent on COX-1 and COX-2, whereas celecoxib = diclofenac < rofecoxib = lumiracoxib < etoricoxib in inhibition of COX-2 (listed in order of increasing average selectivity). Aspirin acetylates and inhibits both enzymes covalently. Low doses (< 100 mg/day) inhibit preferentially, but not exclusively, platelet COX-1, whereas higher doses inhibit both systemic COX-1 and COX-2. 

A topical 3% gel formulation of the nonsteroidal anti-inflammatory drug diclofenac (Solaraze) has shown moderate effectiveness in the treatment of actinic keratoses. The mechanism of action is unknown. As with other NSAIDs, anaphylactoid reactions may occur with diclofenac, and it should be given with caution to patients with known aspirin hypersensitivity (see Chapter 36). 

The well known, beneficial influence of non-steroidal anti-inflammatory drugs (NSAID) on the progress of Alzheimer s disease has been confirmed for some NSAID subtypes. The work by Weggen et al. indicates the potential of COX 1 inhibitors (e.g. Diclofenac, Sulindac, Indomethacin, Ibuprofen, but not the most prominent, Aspirin) in PS inhibition [17]. 

Johnston SA, Leib MS, Forrester SD, Marini M (1995) The effect of misoprostol on aspirin-induced gastrointestinal lesions in dogs. J Vet Intern Med 9 32-38 Matsui H, Murata Y, Kobayashi F et al. (2001) Diclofenac-induced gastric mucosal fluorescence in rats. Dig Dis Sci 46 338-344... 

Diclofenac 50 mg prn Need to change to different pain control as high risk of bleeding when on warfarin and aspirin. Must not be taken as required. 

Diclofenac is contraindicated in those with a history of hypersensitivity to aspirin or another NSAID, severe heart failure, patients with previous or active peptic ulceration, or porphyria. It should be avoided in pregnancy. It should be used with caution in patients with allergic disorders, renal, hepatic and cardiac impairment, the elderly, in lactation and in those with coagulation defects. 

Darunavir (TMC114) Prezista 300 mg tablet Dexamethasone, erythromycins, voriconazole, itrraconazole, ketoconazole, aspirin, fluconazole, NSAIDS, diclofenac topical... 

Topical NSAIDs such as diclofenac sodium 0.1% solution and ketorolac 0.5% solution have been shown to reduce pain associated with corneal abrasions and shorten the time before patients can resume normal activities.The use of topical NSAIDs also reduces the need for oral analgesics however, if pain is not adequately controlled by topical medications, patients may benefit from the use of oral analgesics such as aspirin, ibuprofen. 

ASA = aspirin NSAIDs = non-steroidal anti-inflammatory drugs, such as ibuprofen, naproxen, and diclofenac CNS stimulants include drugs such as pseudoephedrine, dextroamphetamine, theophylline, and caffeine MAO = monoamine oxidase CNS depressants include drugs such as benzodiazepines, barbiturates, and ethanol SSRIs = selective serotonin reuptake inhibitors, such as fluoxetine, sertraline, and paroxetine. Antidiabetic agents include drugs such as insulin, glipizide, glyburide, and metformin. 

In VIGOR, rofecoxib 50 mg/day was associated with a higher rate of non-fatal myocardial infarction (0.4%) than the non-selective COX-2 inhibitor naproxen 500 mg bd (0.1%) (RR = 0.2 Cl = 0.1, 0.7) (33). In CLASS there was no difference in the rates of myocardial infarction in patients taking celecoxib (0.5%) and those taking ibuprofen or diclofenac (0.4%). However, the protocols of the two studies differed substantially with respect to the use of aspirin. In VIGOR, the patients were not allowed to take aspirin or any other antiplatelet drug, while in... 

---