4,4 -Diaminodiphenyl sulfon

The first are competitors of PABA (p-aminobenzoic acid) and thus intermpt host de novo formation of the tetrahydrofoUc acid required for nucleic acid synthesis. Examples of dmgs that fall into this group are the sulfones and sulfonamides. The most weU-known of the sulfones is dapsone (70, 4,4 -diaminodiphenyl sulfone, DDS), whose toxicity has discouraged its use. Production of foHc acid, which consists of PABA, a pteridine unit, and glutamate, is disturbed by the substitution of a sulfonamide (stmcturally similar to PABA). The antimalarial sulfonamides include sulfadoxine (71, Fanasd [2447-57-6]) sulfadiazine (25), and sulfalene (72, sulfamethoxypyrazine [152-47-6] Kelfizina). Compounds of this group are rapidly absorbed but are cleared slowly. 

Diglycidyl ether of bisphenol-A (DGEBA), epoxy resin (YD 128, Kuk Do Chem., Mn = 378), and bisphenol-A dicyanate (BPACY, Arocy B-10, Ciba-Geigy) were used as the thermoset resin. 4,4 -diaminodiphenyl sulfone (DDS, Aldrich Chem. Co.) was used as a curing agent for epoxy. Polyetherimide (PEI, Ultem 1000, General Electric Co., M = 18,000) and 2-methyl imidazole (2MZ, Aldrich Chem. Co.) were used as the thermoplastic modifier and catalyst. 

The solubility of these dyes is significantly enhanced by introduction of alkenyl [35], hydroxypropyl [36], or polyetheralkyl [37] moieties into the trialkylammonium group. The trialkylammonium group may also be a component of a heterocyclic ring [38], When the trialkylammonium residue contains an alkyl chain of more than 11 carbon atoms, the dyes become soluble in aliphatic and alicyclic hydrocarbons and can be used for the production of printing inks [39], With aromatic diamines as the diazo components, such as 4,4 -diaminodiphenyl sulfone, basic disazo dyes are obtained which are suitable for dyeing acid-modified polyamide materials [40],... 

DDS DIAMINODIFENILSULFONA (SPANISH) p,p -DIAMINODIPHENYL SULFONE DIAiMINO-4,4 -DIPHENYL SULFONE 4,4 -DIAMINODIPHENYL SULFONE p,p-DIAMINODIPHENYL SULPHONE DIAMINO-4,4 -DIPHENYL SULPHONE DI(p-AMINOPHENYL) SULFONE DI(4-AMINOPHENYL-)SULFONE DI(p-AMINOPHENYL)SULPHONE DI(4-AMINOPHENYL)SULPHONE DIAPHENYLSULFONE... 

Figure 1. Curing of tetraglycidyl diaminodiphenylmethane with thermally latent catalysts and 4,4 -diaminodiphenyl sulfone.

Analogous para-isomers are obtained from p-chioronitrobenzene (29b). Thus animation with aqueous ammonia at 180 °C and 40 atmospheres gives p-nitroaniline (15a), a useful dye intermediate, manufactured by batch or continuous processes. With sodium sulfide, 4,4 -diaminodiphenyl sulfone (4,4 -sulfonyldianiline), also known as dapsone (32), is obtained, a product used in leprosy treatment and in the manufacture of aramides. 15a... 

Most of the commerically available high-performance moulding materials use epoxidized cresol-novolak/novolak (especially phenolic novolak) as a base. Systems with amine curing agents, for instance 4,4 -diaminodiphenyl-sulfone (2) or 4,4 -diaminodiphenylmethane, do provide high-quality moulding substances with a thermo-mechanical performance comparable to our system. They are, however even less stable under storage. 

Adhesive B. Bulk materials and adhesive film were made with a blend of diglycidyl ether of bisphenol A (DGEBA) epoxy resin in a solid form (epoxy equivalent weight 530), 25 parts, and liquid form (epoxy equivalent weight 190), 75 parts, and were cured with 4,4 -diaminodiphenyl sulfone (DDS, amine equivalent weight 64), 28 parts, and toughened with the core-shell polymers, 0 or 15 parts (Table II). 

Effect of Rubber on Stress-Whitening in Epoxies Cured with 4,4 -Diaminodiphenyl Sulfone... 

In fact, the photochemical process is much less sensitive to the rigidity of the system if the azobenzene is attached as a side chain. Copolymer ABA-MMA exhibited a quantum efficiency only 4-5 times lower in a glassy film then in dilute solution (8). By contrast, Figure 3 shows the relative quantum efficiencies for the trans-cis isomerization of a copolyamide of isophthalic acid with 4,4 -diaminodiphenyl sulfone containing a small proportion of... 

Diaminodiphenyl sulfone may be considered the first major advance in the chemotherapy of tuberculosis. However, it was overshadowed a few years later by streptomycin. DDS did find an important place in the treatment of leprosy following its first clinical use in 1943. 

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