4,4’-Diaminodiphenyl sulphone

Most analytical work on sulphones has naturally been concerned with the compounds synthesized for special purposes, e.g. sulphonal, trional and tetronal as sedatives and hypnotics Sulphenone (4-chlorodiphenyl sulphone) and Tedion (2,4,4, 5 -tetrachlorodiphenyl sulphone) as acaricides 4,4 -diaminodiphenyl sulphone as an antileprotic. In choosing examples preference has been given to methods devoted to more than a single sulphone. 

Most of the examples concern substituted diphenyl sulphones, with the anti-leprotic agent 4,4 -diaminodiphenyl sulphone taking a prominent place. Cates and Meloan56 separated aliphatic, aromatic and cyclic sulphones using helium carrier gas and thermal... 

In diamines such as 4,4 -diaminodiphenylmethane, 4,4 -diaminodiphenyl sulphone or 1,6-hexamethylenediamine, the substitution effect is practically absent641 although this may not be the case for di- and polyamines where the distance between the amino groups is not large allowing inductive and steric effects to be operative 59,68 ... 

Diaminodiphenyl sulphone and related drugs are chromatographed as 4,4 -diiodo derivatives. The amino groups are diazotized by treatment with nitrous acid and substituted with iodine, and the resulting derivative provides a high ECD response [568]. 

As almost all foreign compounds are distributed via the bloodstream, the components of the blood are exposed at least initially to significant concentrations of toxic compounds. Damage to and destruction of the blood cells results in a variety of sequelae such as a reduced ability to carry oxygen to the tissues if red blood cells are destroyed. Aromatic amines such as aniline and the drug dapsone (4,4-diaminodiphenyl sulphone) are metabolized to hydroxylamines, and in the latter case the metabolite is concentrated in red blood cells. Also, nitro compounds such as nitrobenzene, which can be reduced to hydroxylamines, are similarly toxic to red blood cells. These hydroxylamines are often unstable and can be further oxidized to reactive products, in the presence of oxygen in the... 

Diaminodifenylsulfon 4,4 -Diaminodiptienyl sulfone 4,4 -Diaminodiphenyl sulphone Dapsone Dapsonum DDS DDS... 

Recent work by Kong and Park [64] likewise defined an exfoliation process which occurs in three distinct steps or stages (rather than a gradual process) for the isothermal cure of DGEBA with 4,4 -diaminodiphenyl sulphone (DDS) and an octadecylammonium-treated montmorillonite. Figmell... 

Dapsone is 4,4 -diaminodiphenyl sulphone and it may be assayed by titration with sodium nitrite using a dead-stop end-point. 

Prepare a series of standard solutions containing 1 to 0 5 mg of 4,4 -diaminodiphenyl sulphone in 100 ml by suitably diluting with water a 1 per cent solution in dilute hydrochloric acid. Treat 10 ml of each standard solution successively with 0 4 ml of concentrated hydrochloric acid, 1 ml of 0 1 per cent sodium nitrite solution, 10 ml of ethanol and 1 ml of a 1 per cent ethanolic solution of dimethyl-a-naphthylamine. Mix thoroughly and after ten minutes measure the extinction at the absorption maximum at about 550 m/u. Prepare a standard curve from the readings obtained. 

Prepare a solution of the solapsone under examination, so that it will possess a content of 4,4 -diaminodiphenyl sulphone within the range covered by the standard curve, making due allowance for moisture and for the fact that only 80 per cent recovery is usual. Mix 10 ml of the solution with 0-4 ml of concentrated hydrochloric acid and heat in a water-bath for twenty minutes. Cool, make up the volume to 10 ml with water and treat by the process described above for the standard solutions. After taking the extinction reading use the standard curve to obtain the result of the assay, which may be expressed in terms of anhydrous solapsone or dapsone. 

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