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Development controls

The standard requires the supplier to develop control plans using a multidisciplinary approach at the system, subsystem, component, and/or material level for pre-launch and production and prototype when required. [Pg.208]

By identifying the potential sources of failures, it is possible to develop controls to address those hazards. These controls might be passive physical items (e.g., dikes, walls, vents), active physical systems (e.g., fire suppression, pressure limiters, temperature controls), or administrative procedures. [Pg.121]

Calpain inhibition may represent an important mechanism for future drug development. Control of calpain activity may limit the invasive properties of cells and thereby provides a possible mechanism to limit the invasiveness of tumors or inhibits the development of chronic inflammation. For the moment, pharmacological inhibitors of calpains are still not capable of differentiating among different calpain isoforms in cellular systems or in vivo. The importance of calpains in diseases will continue to stimulate the development of new and better inhibitors. [Pg.313]

Bovine growth hormone, a difficult protein for which to develop controlled release systems due to its propensity toward self-aggregation and inactivation, has successfully been incorporated into polyanhydride matrices (18). The growth hormone was colyophilized with sucrose, dry-mixed with finely powdered polyanhydride, and then compression molded into 1.4-cm-diaraeter wafers, 1 mm thick. As is shown in Fig. 15, release of bovine growth hormone was well controlled over a prolonged period of time. The assay for bovine... [Pg.60]

Furylcarbinols with protic acids (fluoroboric acid) may merely give car-benium (furylium) salts.171 Similar cations are accessible via 2-furyldiazo-methane derivatives,172 but in many cases ring opening and prototropic shifts ensue as in Marckwald reactions (Scheme 30).173 A recent development controls solution acidity by using magnesium or zinc ions instead of protons... [Pg.199]

Finally if you combine many of the concepts above, you can begin to think about developing controlled reaction centers that combine inorganic, organic,... [Pg.462]

Early response genes function as development-control signals 444... [Pg.437]

Early response genes function as development-control signals. How do epigenetic influences participate in decision making Environmental influences come in the form of growth factors, neurotransmitters and other ligands that are linked to changes in membrane receptors and... [Pg.444]

Determining the potential for hazards to result in an accident (risk assessment) is frequently part of the identification step (see chapter 11). This list of potential hazards and their risk is used during the evaluation and control phase of the project. Resources for evaluating the hazards and developing control methods are allocated on a priority basis, giving the appropriate time and attention to the most significant hazards. [Pg.74]

A hormone is a chemical that transfers information and instructions between cells in animals and plants. They are often described as the body s chemical messengers , but they also regulate growth and development, control the function of various tissues, support reproductive functions, and regulate metabolism (i.e. the process used to break down food to create energy). [Pg.387]

Since the equatorial substituents are more stable than axial substituent, the product development control gives mainly the equatorial alcohol unless the steric hindrance to the approach of the reagent is very severe. [Pg.286]

The next step in developing controlled degradation polyester is to understand expectations for specific product applications. Some questions to be answered include the following ... [Pg.593]

The additions of nucleophiles to ketones have been classified as governed either by product development control or by steric... [Pg.161]

The same aplies to polymer brushes. The use of SAMs as initiator systems for surface-initiated polymerization results in defined polymer brushes of known composition and morphology. The different polymerization techniques, from free radical to living ionic polymerizations and especially the recently developed controlled radical polymerization allows reproducible synthesis of strictly linear, hy-perbranched, dentritic or cross-linked polymer layer structures on solids. The added flexibility and functionality results in robust grafted supports with higher capacity and improved accessibility of surface functions. The collective and fast response of such layers could be used for the design of polymer-bonded catalytic systems with controllable activity. [Pg.434]

Hydrides and complex hydrides tend to approach the molecule of a compound to be reduced from the less hindered side steric approach control). If a relatively uninhibited function is reduced the final stereochemistry is determined by the stability of the product (product development control). In addition, torsional strain in the transition state affects the steric outcomes of the reduction. [Pg.20]

PRODUCT-DETERMINING STEP PRODUCT DEVELOPMENT CONTROL Product formation,... [Pg.774]

If this interpretation is correct, then in any reaction with asymmetric induction, a search for antiperiplanarity between the incipient bond (Nu-Cl) and an adjacent sigma bond (C2-L) should lead to the most favourable transition states, all other things being equal. Let us apply this rule to the so-called product development control problem. Consider a conformationally fixed cyclohexanone, for example 14. [Pg.105]

Monitoring and regulating medicine promotion to ensure that it is ethical and unbiased. AU promotional claims should be rehable, accurate, truthful, informative, balanced, up-to-date, capable of substantiation and in good taste. WHO s ethical guidelines (1988) may be used as a basis for developing control measures... [Pg.90]

Der von Berson diskutierte Reaktionsablauf tragt gewisse Ziige eines Modells mit product development control" (34). [Pg.9]


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See also in sourсe #XX -- [ Pg.143 , Pg.156 , Pg.157 ]




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