Development cell adhesion molecules

Regan CM. 1993. Neural cell adhesion molecules, neuronal development and lead toxicity. Neurotoxicology 14 69-74. 

Halichlorine 11 is a structurally unique alkaloid that was isolated from the sponge Halichondria okadai and found to act as an inhibitor of the induction of vascular cell adhesion molecule (VCAM-1), a potential target in the development of drugs for the treatment of several vascular diseases. The strategies employed for the construction of its spiroquinolizidine unit are summarized in Scheme 106. 

Cell adhesion molecules (CAMs) play critical roles in all facets of nervous system development and maintenance. Important phenomena in which CAMs are involved include initial formation of the neural tube and the neural crest, migration of all neurons and glial cells, axonal outgrowth and guidance, target selection, synaptic stabilization and plasticity, myelination and nerve regeneration after injury (see Chs 4,24,28-30 and 53). Adhesion molecules interact with each other and with nonadhesive cell-surface and/or cytoplasmic molecules, and, in the two... 

There are multicellular interactions that are important in inflammatory processes and in vascular remodeling. Activated platelets induce endothelial cells to secrete chemokines and to express adhesion molecules, indicating that platelets could initiate an inflammatory (Table I) response of the vessel wall. Activated platelets promote leukocyte binding to inflamed or atherosclerotic lesions (27,28). Cell adhesion molecules (CAMs) are responsible for leukocyte-endothelium interactions. It plays a crucial role in inflammation and atherogenesis. Vascular CAM-1 (VCAM-I)and intracellular CAM-1 (ICAM-I) promote monocyte recruitment to sites of injury and constitute a critical step in inflammation and in atherosclerotic plaque development. TSP-1, a matricellular protein released in abundance from activated platelets and accumulated in sites of vascular injury, induces the expression of VCAM-1 and ICAM-1 on endothelium and significantly increases the monocyte attachment (29). 

Miyazaki, K. Makino, K. Iwadate, E. Deguchi, Y. Ishikawa, F. 2008. Anthocyanins from purple sweet potato Ipomoea batatas cultivar Ayamurasaki suppress the development of atherosclerotic lesions and both enhancements of oxidative stress and soluble vascular cell adhesion molecule-1 in apolipoprotein E-deficient mice. J. Agric. Food Chem. 56 11485-11492. 

Vanderslice P, Biediger RJ, Woodside DG, Berens KL, Holland GW Dixon RA. Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD. Pulm. Pharmacol. Ther. 2004 17 1-10. 

Cell adhesion molecules (CAMs) are transmembrane glycoproteins that act at the cell surface to mediate specific binding interactions with other cell adhesion molecules on adjacent cells or with proteins in the extracellular matrix. They are responsible for the adhesion of various leukocytes with each other, with extracellular matrix and with other cell types. Several classes of molecules capable of mediating adhesion include selectins, integrins, cadherins, and immunoglobulin superfamily members [263-265]. Multiple members from every major family of cell adhesion molecules have been implicated in the development, maintenance, or repair of renal tissues... 

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