Developing lipid

Weiner, A.L. Developing lipid-based vehicles for peptide and protein drugs. Part I selection and analysis issues. Biopharm. 1990, 3 (3), 27-32. 

Di Marzo V. De Petrocellis L, Bisogno T, Melck D (1999b) Metabohsm of anandamide and 2-arachidonoylglycerol an historical overview and some recent developments. Lipids 34 319-325... 

Anon (2001) Improved cottonseed oils developed. Lipid Technol. Newsletter, 7, 53-54. 

From an in vitro perspective, solubility in water and in organic solvents determines the choice of solvent, which, in turn, influences the choice of extraction procedure and analytical method. Solubility can also indirecfly impact the timeframe of an assay for compounds that are unstable in solution. From an in vivo perspective, the solubility of a compound influences its absorption, distribution, metabolism, and excretion. Both water solubility and lipid solubility are necessary for the absorption of orally administered antimicrobial drugs from the gastrointestinal tract. This is an important consideration when selecting a pharmaceutical salt during formulation development. Lipid solubility is necessary for passive diffusion of drugs in the distributive phase, whereas water solubility is critical for the excretion of antimicrobial drugs and/or their metabolites by the kidneys. 

Ravandi, A., Babaei, S., Leung, R., Monge, J.C., Hoppe, G., Hoff, H., Kamido, H., and Kuksis, A. 2004. Phospholipids and oxophospholipids in atherosclerotic plaques at different stages of plaque development. Lipids, 39, 97-109. 

Storry, J. E. and Tuckly, B. (1967) Thin-layer chromatography of plasma lipids by single development. Lipids, 2, 501-2. 

GISBERT E, VILLENUEVE L, ZAMBONESTO-INFANTE J.L, QUAZUGUEL P, CAHU C.L (2005) Dietary phospholipids are more efficient than neutral hpids for long chain polyunsaturated fatty acid supply in european sea bass Dicentrarchus labrax larval development. Lipids, 40, 609-618. 

R.E. Timms, Lipid Technologies and Applications (ed. F.D. Gunstone and F.B. Padley) Marcel Dekker, New York (1997), pp.199-222. DA. Allen, Fat modification as a tool for product development. Lipid Technology, 1998,10, 29-33. E. Deffense, Dry multiple fractionation trends in products and applications. Lipid Technology, 1995, 7, 34-38. T. Willner and K. Weber,... 

M. Lassner, Transgenic oilseed crops a transition from basic research to product development. Lipid Technology, 1997, 9, 5-9. V.C. Knauf and A.J. Del Vecchio, Food Lipids Chemistry, Nutrition, and Biotechnology, (ed. C.C. Akoh and D.B. Min) Marcel Dekker, New York (1998) pp.779-805. 

A cross-sectional study, ARIC, suggest that Lp(a) is a risk factor for preclinical and clinical atherosclerosis (446). However, it was found to be an independent factor associated with thickening of common carotid arteries only in severely hypercholesterolemic patients, and not in patients with moderately elevated or normal levels of blood cholesterol (447). Also, Lp(a) transgenic mice develop lipid lesions in aorta more frequently than nontransgenic animals even on a low-fat diet (448). 

Watanabe, K., Yasugi, E., Oshima, M. (2000) How to search the glycoUpid data in LIPID-BANK for Web The newly developed lipid database. Japan Trend Glycosci. Glycotechnol. 12,175-184. 

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