Design and synthesis

Hanessian and Devasthale, 1996] Hanessian, S., and Devasthale, P. Design and synthesis of novel, pseudo C2 symmetric inhibitors of HIV protease. Bioorg. Med. Chem. Lett. 6 (1996) 2201-2206... 

G. Van Binst, ed.. Design and Synthesis of Organic Molecules Rased on Molecular Recognition, Springer, New York, 1986. 

There is increasing pressure to develop homochiral dmgs (34). Growing demands are faced by the pharmaceutical industry in dmg development to consider chiral issues in the eady preclinical phases of dmg design and synthesis. 

A. T. Peters and H. S. Preeman, Color Chemistry The Design and Synthesis of Organic Dyes and Pigments, Elsevier, London, 1991. 

P. Gregory, High-Tech Applications of Organic Colorants, Plenum Press, New York, 1992 P. Gregory, in A. T. Peters and H. S. Freeman, eds.. Colour Chemistry (The Design and Synthesis of Organic Dyes and Pigments), Elsevier AppHed Science, New York, 1991, p. 193. 

It is apparent that the use of enzymatic catalysis continues to grow Greater availabiUty of enzymes, development of new methodologies for thek utilization, investigation of enzymatic behavior in nonconventional environments, and the design and synthesis of new biocatalysts with altered selectivity and increased stabiUty are essential for the successhil development of this field. As more is learned about selectivity of enzymes toward unnatural substrates, the choice of an enzyme for a particular transformation will become easier to predict. It should simplify a search for an appropriate catalyst and help to estabhsh biocatalytic procedures as a usehil supplement to classical organic synthesis. 

Novel Methods for Selective Huorination of Organic Compounds. Design and Synthesis of Fluorinated Antimetabolites Kollonitsch, J Isr J Chem 17, 53-59 50... 

R. T. Oakley, Chemical Binding Within and Between Inorganic Rings The Design and Synthesis of Molecular Conductors, Can. J. Chem., 71, 1775 (1993). 

Design and synthesis of conformationally fixed amino acids of heterocyclic series as versatile building blocks 97T12789. 

Design and synthesis of analogs of dynemycin, antitumor antibiotic with an-thraquinone, 10-member enediyne, tetrahydropyridine, and oxirane fragments 99EJ01. 

Design and synthesis of glutathione analogs containing heterocyclic fragments 98F721. 

Design and synthesis of crown ethers and other macroheterocycles as highly selective ionophores for chemical ion sensors 98YGK291. 

Bmin P, Veensda GJ, Nijenhuis AJ, and Pennings AJ. Design and synthesis of biodegradable poly(ester-urethane) elastomer networks composed of non toxic building blocks. Makromol Chem Rapid Common, 1988, 9, 589. 

In light of the importance of the / -turn motif in peptide and protein recognition, and the design and synthesis of bioactive small molecules, / -turn mimetics has attracted considerable attention. Seebach and coworkers have shown recently that low molecular weight open-chain / - and y-peptides designed to promote turn formation can be used as templates for mimicking the a-peptide hormone somatostatin. 

The opportunities for biomedical membrane design and synthesis in the pol3q>hosphazene system are wide ranging. So far, only preliminary explorations have been undertaken, and only a brief outline will be given here. 

Methodologies for the de novo design and synthesis of polypeptides were recently developed. The preparation of periodic polypeptides, polypeptides containing artificial amino acids, polypeptides exhibiting rodlike structures, and hybrids of natural and artificial polypeptide segments was recently described [33],... 

Iwata Y, Arisawa M, Hamada R, Kita Y, Mizutani MY, Tomioka N, Itai A, Miyamoto S. Discovery of novel aldose reductase inhibitors using a protein structure-based approach 3D-database search followed by design and synthesis. J Med Chem 2001 44 1718-28. 

Richard S. H. Mah and Mordechai Shacham, Pipeline Network Design and Synthesis J. Robert Selman and Charles W. Tobias, Mass-Transfer Measurements by the Limiting-Current Technique... 

Dondoni, A. Massi, A. (2006) Design and Synthesis of New Classes of Heterocyclic C-Glycoconjugates and Carbon-Linked Sugar and Heterocyclic Amino Acids by Asymmetric Multicomponent Reactions (AMCRs). Accounts of Chemical Research, 39, 451M63. 

Table 1 Guidelines for the design and synthesis of an immunogen hapten...

Nakamura K, Hanai N, Kanno M, Kobayashi A, Ohnishi Y, Ito Y, Nakahara Y. Design and synthesis of silyl ether-based linker for solid-phase synthesis of glycopeptides. Tetrahedron Lett 1999 40 515-518. 

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