Synthesis Design and Execution

Given the relative complexity of most APIs, there is a continuing need to develop chemo-, regio- and stereoselective reactions to reduce the levels of waste generated in their syntheses. From the 1980s onwards there was a surge in the use of cryo- 

The survey of reactions used to prepare small-molecule APIs [9] highlighted reactions warranting research to identify greener options for the process chemist, and a subsequent paper by members of the ACS Roundtable substantially expanded this perspective [12]. The following subsections focus on three chemical transformation areas requiring future development, but the reader is referred to the Roundtable reference for a more extended discussion. 

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