Design and Synthesis of Methacrylate-based Copolymers

Based on the peptide-mimetic design, Kuroda and Degrado [24] studied antimicrobial polymers, using the conventional polymer platform of methacrylate, which have no 

Palermo, K. Yasuhara, K. Knroda Gregory and A. Caputo, Macromolecular Bioscience, 2013, 13, 1285. 2013, John Wiley and Sons [26] 

The polymers were synthesised from boc-protected amine monomers and alkyl or benzyl methacrylate monomers. The polymerisation was performed by applying AIBN, as a radical initiator, and methyl 3-mercaptopropionate, as a chain transfer agent, in acetonitrile. The treatment of boc-protected polymers with TFA produced amphiphilic random copolymers with cationic ammoninm groups in the side chains. 

Dizman and co-workers [27] prodnced new methacrylate monomers enclosing pendent biquaternary ammonium moieties based on l,4-diazabicyclo-[2.2.2]-octane (DABCO) 

Pumyani and Singh [28] described the synthesis of iodine-containing quaternary amine methacrylate (QAMA) copolymers. The monomers were prepared via a two-step reaction i) the reaction of ethylene glycol dimethacrylate with piperazine in methanol at 35 °C and ii) the quaternisation of the synthesised monomer with 1-iodooctane. The antimicrobial activities of the QAMA-containing copolymers were evaluated against Escherichia coli and Staphylococcus aureus. 

---