NMR-based protein structures

NOE, a relaxation mechanism based upon magnetic dipole-dipole interactions of the nuclei, allows measurement of interproton distances with the basic r distance proportionality. This provides major distance restraints for strucmral calculations. Supplemented with additional data, such as original dihedral angle restraints obtained from J-coupUngs or more recent information about the orientation of the bond vectors connecting magnetically active nuclei with respect to the external magnetic field, this approach has been the foundation for NMR-based protein structure determination since its dawn in 1984 [11]. [Pg.39]

R 645 L. Zeng, C. H. Chen, M. Muller and M. -M. Zhou, Structure-Based Rational Design of Chemical Ligands for AMPA-Subtype Glutamate Receptors , J. Mol. Neurosci., 2003,20, 345 R 646 S. Zhou, Separation and Detection Methods for Covalent Drug-Protein Adducts , J. Chromatogr., B, 2003,797, 63 R 647 I. Zhukov and A. Ejchart, NMR Spectroscopy in Structural Proteomics. NMR-Based Protein Structure Determination , Polimery (Warsaw, Poland), 2003, 48, 28... [Pg.47]

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