Dermatological agents corticosteroids

Chloromethyidimethylchlorosilane derivatizing corticosteroids Dimethyidiacetoxysilane dermatitis, chronic humans Potassium arsenite dermatologic agent o-Thiocresol p-Thiocresol dermatologic pharmaceuticals Sulfurated potash dermatological treatment Lactic acid dermatology... 

The remarkable efficacy of topical corticosteroids in the treatment of inflammatory dermatoses was noted soon after the introduction of hydrocortisone in 1952. Numerous analogs are now available that offer extensive choices of potencies, concentrations, and vehicles. The therapeutic effectiveness of topical corticosteroids is based primarily on their antiinflammatory activity. Definitive explanations of the effects of corticosteroids on endogenous mediators of inflammation await further experimental clarification. The antimitotic effects of corticosteroids on human epidermis may account for an additional mechanism of action in psoriasis and other dermatologic diseases associated with increased cell turnover. The general pharmacology of these endocrine agents is discussed in Chapter 39. 

These include atypical or subtle manifestations of dermatologic conditions such as seborrheic dermatitis, rosacea, psoriasis, atopic dermatitis, and ichthyosis. Classic manifestations of such diseases are diagnosed with relative ease. However, diagnostic difficulty arises in the presence of atypical morphology, lesions masked by topical therapy (e.g., corticosteroids), or exacerbations due to other topical agents (e.g., skin care products).2,10... 

The cream and ointment contain alclometasone dipropionate [7(alpha)-chloro-ll(beta),17,21-trihydroxy-16(alpha)-methylpregna-1,4-diene- 3,20-dione 17,21 -dipropionate)], a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Each gram of cream contains 0.5 mg of alclometasone dipropionate in a hydrophilic, emollient... 

Clotrimazone cream and lotion contain combinations of clotrimazole, a synthetic antifungal agent, and betamethasone dipropionate, a synthetic corticosteroid, for dermatologic use. Chemically, clotrimazole is l-(o-chloro-(alpha),(alpha)-diphenylbenzyl) imidazole, with the... 

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