Dermatitis lithium treatment

Dreno B, Chosidow O, Revuz J, Moyse D. Lithium gluconate 8% vs ketoconazole 2% in the treatment of sebor-rhoeic dermatitis a multicentre, randomized study. Br J Dermatol 2003 148(6) 1230-6. 

Dreno B, Moyse D. Lithium gluconate in the treatment of seborrhoeic dermatitis a multicenter, randomised, doubleblind study versus placebo. Eur J Dermatol 2002 12(6) 549-52. 

Lithium carbonate (Li2C03) treatment is used worldwide for the prophylactic treatment of bipolar affective disorder. Although the molecular mechanism(s) of action remains uncertain, the efficacy is well-demonstrated and can be maintained by continued use of the drug. Lithium succinate is used to treat seborrheic dermatitis, a skin disorder. Other uses currently being explored include treating immunological disorders and cancers. Schrauzer has proposed that lithium may be an essential trace element and has suggested a daily intake of 1.00 mg day . ... 

Lithium succinate (Efalith) and lithium gluconate are effective topical treatments for seborrheic dermatitis, which affects the face and other oil-secreting areas of the body. The causative agent has been identified as the yeast, Pityrosporum Two British multicenter double-... 

Lithium succinate ointment also has proved to be useful in the treatment of seborrhoeic dermatitis, having an effect both on the lipid metabolism of the normal skin fungus, Pityrosporum ovale, which proliferates excessively in this condition, and on the general inflammatory effect, which is the normal response to such fungal attack (212, 213). Further extensions of the antiviral and topical uses are expected and the area is rapidly developing. 

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