Dementia risk factors

McArthur JC (2004) HIV dementia an evolving disease. J Neuroimmunol 157(l-2) 3-10 McArthur JC, Hoover DR, BaceUar H, MUler EN, Cohen BA, Becker JT, Graham NM, McArthur JH, Seines OA, Jacobson LP et al (1993) Dementia in AIDS patients incidence and risk factors. Multicenter AIDS Cohort Study. Neurology 43(ll) 2245-2252 McManus CM, liu JS, Hahn MT, Hua LL, Brosnan CE, Berman JW, Lee SC (2000) Differential induction of chemokines in human microgUa by type I and II interferons. GUa 29(3) 273-280 McQuibban GA, Butler GS, Gong JH, BendaU L, Power C, Clark-Lewis I, OveraU CM (2001) Matrix metaUoproteinase activity inactivates the CXC chemokine stromal ceU-derived factor-1. J Biol Chem 276(47) 43503 3508... 

Wong MH, Robertson K, Nakasujja N, Skolasky R, Musisi S, Katabira E, McArthur JC, Ronald A, Sacktor N (2007) Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology 68(5) 350-355... 

McArthur JC, Hoover DR, Bacellar H, Miller EN, Cohen BA, Becker JT, Graham NM, McArthur JH, Seines OA, Jacobson LP et al (1993) Dementia in AIDS patients incidence and risk factors. Multicenter AIDS Cohort Study. Neurology 43(ll) 2245-2252... 

Alzheimer s disease is the most common form of age-related dementia and one of the most serious health problems in the industrialized world. AD is an insidious and progressive neurodegenerative disorder that accounts for the vast majority of dementia and is characterized by global cognitive decline and the accumulation of P-amyloid deposits and neurofibrillary tangles in the brain. Family history is the second greatest risk factor for... 

Dementia is a major risk factor for delirium. Many illnesses may increase the risk of delirium. Infections, cardiac, metabolic and of course diseases in the central nervous system may all make elderly more vulnerable to delirium. Vision impairment and functional impairment are also well-known risk factors as well as premorbid cognitive impairment (Korevaar et al. 2005, Inouye et al. 2007). 

Korevaar JC, van Munster BC, de Rooij SE (2005) Risk factors for delirium in acutely admitted elderly patients a prospective cohort study. BMC Geriatr 5 6 Kudoh A, Takase H, Takahira Y et al. (2004) Postoperative confusion increases in elderly longterm benzodiazepine users. Anesth Analg 99 (6) 1674-1678 McCusker J, Cole M, Dendukuri N et al. (2001) Delirium in older medical inpatients and subsequent cognitive and functional status a prospective study. Cmaj 165 (5) 575-583 McCusker J, Cole M, Dendukuri N et al. (2003) The course of delirium in older medical inpatients a prospective study. J Gen Intern Med 18 (9) 696-704 McShane R, Areosa Sastre A, Minakaran N (2006) Memantine for dementia. Cochrane Database Syst Rev 19 (2) CD003154... 

Skoog I. (1979). Status of risk factors for vascular dementia. Neuroepidemiology. 17(1) 2-9. 

For many years, alterations in APOE and defects in the APOE gene have been associated with dysfunctions in lipid metabolism, cardiovascular disease, and atherosclerosis. During the past 25 years, an enormous amount of studies clearly documented the role of APOE-4 as a risk factor for AD, and the accumulation of the APOE-4 allele has been reported as a risk factor for other forms of dementia and CNS disorders (1,12,18-20,47.488). 

Cardiovascular and cerebrovascular disorders associated with lipid metabolism disturbance and atherosclerosis represent major risk factors for dementia (3,25,59). Atherosclerosis is the primary cause of heart disease and stroke in which genetic and environmental factors converge (553). More than 90% of patients older than 70-80 yr with dementia show signs of atherosclerosis in their arteries and a clear cerebrovascular component in their dementia process. It is very likely that pure AD is practically absent in octogenarians, in whom the prevalent diagnosis is vascular or mixed dementia (3,25,59), in which the APOE-4 allele also accumulates (18-20,554). 

Table 10.1 shows the proposed risk factors for Alzheimer s disease, the most common cause of dementia. Heading this list is of course old age. But be careful how you... 

The risk factors for vascular dementia are essentially the same as those for stroke and heart attack. They include high blood pressure, heart disease, diabetes mellitus, sickle cell disease, obesity, smoking, alcohol use, depression, and high cholesterol levels. 

Dementia has reached epidemic proportions with an estimated 4.6 million new cases worldwide each year... it is a true disease, cause by exposure to several genetic and non-genetic risk factors. 

Dementia due to AD steadily worsens, typically over the course of about 10 years, but survival in some patients may be as short as 3 4 years. In late stages AD leads to what is sometimes called a vegetative state, Le. the patient is bedfast and totally dependent on others for all basic living activities. Patients with AD typically die from bronchitis or pneumonia. Risk factors of AD are age, female gender and presence of the apolipoprotein c4 (APO e4) allele. Higher levels of education, moderate levels of daily wine consumption and higher levels of fish in the diet have been associated with a lower risk for AD (Cummings and Cole, 2002). 

Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer s disease. N Engl J Med 2002 346(7) 476-483. 

Forster DP, Newens AJ, Kay DWK, et al. 1995. Risk factors in clinically diagnosed presenile dementia of the Alzheimer type a case-control study in northern England. J Epidemiol Commun Health 49 253-258. 

Many individuals with LA also harbor lacunar and/or cortical infarcts. Presence of LA serves as an intermediate surrogate both for ischemic stroke and intracerebral hemorrhage as they all share similar risk factors and similar pathophysiological mechanisms (Inzitari 2003). LA is widely found in dementing illnesses, such as Alzheimer s disease, vascular dementia, and cerebral autosomal dominant arteri-opathy with subcortical infarcts and leukoencepha-lopathy (CADASIL). Failure of blood supply in the... 

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