Delivery logic

Table 14.1. Organic growth issues defining the business and delivery logics... 

The second requisite logic is what we call the delivery logic. This defines the operational and organizational capabilities that cost-effectively distribute products and services to customers consistent with... 

Equally important to the success of a replicution strategy is the delivery logic. Building on the examples in this book, the major elements... 

At this point, a growth spurt is likely. The firm now has in place twin logics. One is concerned with the business itself and the other with how products and services can be brought to customers. The original mix will likely be altered incrementally to meet changing needs, but the essence of the idea behind the business and delivery logics will remain intact. 

The availability and delivery logic of different breath types define the mode of mechanical ventilation (3,4). The mode controller provides a combination of breaths, according to algorithms and feedback data (Table 1). Newer designs incorporate advanced... 

The definition of the cost model is of crucial importance for controlling the behavior of the S N P optimizer. One of the central questions is whether to maximize service level, which usually means using high penalties for non and late delivery, or to maximize profits, which requires the use of realistic sale prices. In the case study scenario, the nondelivery cost levels reflect real sale prices sufficiently close to enable a profit maximization logic. 

A review of GI transit and oral drug absorption can be organized in many ways, but a logical sequence is to start at the top and work down. In this review, techniques to study buccal and rectal delivery will not be covered, but a detailed description of these is available in a recent book (1). 

The experimentally derived empirical expressions used in models such as the mass-action framework have contributed greatly to the logical selection of surfactants for efLcient and effective solubilization of drugs. However, there is currently a need to develop more efLcient, less toxic surfactants for use in drug delivery. A model that is able to provide quantitative prediction of the critical micelle concentration and micelle size without the need for extensive experimental measurements would greatly accelerate the development of novel surfactant chemistries for use in pharmaceutical applications. 

It is also clear from the data presented in this chapter that care must be taken when applying any of the above-proposed solutions. Logical selection of excipients and rational design of lipid-based formulations or prodrug synthesis tailored for drug candidates are key factors for the success of these delivery systems. 

Disaccharides can have similar utility to monosaccharides in DNA delivery polymers. Trehalose, a disaccharide composed of two glucose units linked via an a-(l—>1) glycosidic bond, has been shown to have cryo- and lyo-protective properties, attributed to an unusually large hydration volume [152]. As a function of these properties, trehalose has been shown to prevent aggregation and fusion of proteins and lipids [153]. Logically, incorporation of these features into a polymer backbone could afford similar characteristics to a DNA delivery system and may prevent aggregation of polyplexes in physiological serum concentrations and ionic... 

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