Effect of solubilization

Saha, P. and J. Kou. Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers., Eur. 

In this equation, the value of (Red) is a function of the nature of the reductant, its solubility, the crystallinity of solid phases containing it, effects of solubilizing agents, transport limitations, and other factors. Likewise the value of (Ox) is a function of various factors. As discussed in the previous chapter, most redox reactions are very slow and the prevailing conditions are therefore sensitive to catalysis. Three types of catalysis are involved ... 

Since oleic acid is relatively polar, it may become emulsified by the surfactant monomer. The removal of oleic acid comes mainly from two contributions monomer emulsification and micellar solubilization. Although the Vgjj has been decreased with increasing EO number in dodecanol ethoxylates, in higher EO numbers than 5, this factor has been compensated by the Increase of monomer with increasing EO number (CMC decreases with EO number). The levelling of detergency of dodecanol ethoxylates from EO number 5 to EO number 8 has been interpreted by these reasons. The monomer emulsification of oleic acid has been clearly shown in this paper in SDS solution. The nonionic surfactants we used here have low EO numbers and show mainly the effect of solubilization. 

For oral liquids, taste masking becomes essential. The effects of solubilizing agents such as complexing agents and cosolvents on taste need to be evaluated. 

Figure 3 shows the effect of solubilization upon equilibrium in the particular system we used. The data were obtained many years ago by R. J. Williams (24) and agree excellently with recent results of H. Schott (23). The solubilized substance was a brilliant dye whose solubility in... 

Thoma K, Pfaff G. Use of solubilizers as adjuvants in the production of drugs. Part 5. Effect of solubilization with polyethylene glycol-glycerol fatty acid esters on the photostability of menadione. Pharmazie 1976 31(7) 477- 0. 

The modulatory role of solubilizers on drug efflux by Pgp and in silico prediction of the effect of solubilizers on Pgp are some of the newer goals of preformulation studies. 

III. SOME EFFECTS OF SOLUBILIZATION III.A. Effect of Solubilization on Micellar Structure... 

FIGURE 4-4 Effect of solubilization content and other molecular environmental factors on micellar structure. Note that interconversion of normal and reverse lamellar micelles involves only small changes in distances between hydrophilic and hydrophobic groups. 

Other useful effects of solubilization are the binding of organic acids soluble in lubricating oils to the cations of metal sulfonate detergents in these oils, thereby decreasing the corrosion of metals by these acids (Bascom, 1958) and the solubilization of foamicidal oils by foam-producing surfactants, leading to increased foam life. 

Toernblom, M. and Henriksson, U. (1997) Effect of solubilization of aliphatic hydrocarbons on size and shape of rodlike Cl 6TABR micelles studied by 2H NMR relaxation. /. Phys. Chem. B, 101, 6028-6035. 

Effect of Solubilized Oil. Figure 21 shows the interferogram of a foam film formed from the nonionic Enordet AE1215-30 (ethoxylated... 

The addition of small amounts of nonsurfactant organic materials of low water solubility will often produce an apparent increase in micelle size, although that may be more an effect of solubilization (see text below) than an actual increase in the number of surfactant molecules present in the micelle. 

The effects of solubilized additives on the micellar properties of nonaqueous surfactant systems vary according to the structures of Ae components. Such changes, however, are often greater than those found in aqueous solutions, so that due care must be exercised in evaluating the effects of even small additions on the aggregation characteristics of surfactants in nonaqueous solvents. 

Mitra, S. Dimgan, S. R. Micellar Properties of Quillaja Saponin. 2. Effect of Solubilized Cholesterol on Solution Properties. Colloids Surf. B 2000,17,117-133. 

The second effect of solubilized alcohol molecules is the change of local dielectric constant in the palissade layer, due... 

In a recent report, the effect of solubilizing EA and OA on the nanostructure of fully hydrated monoelaidin (ME, a neutral rod-like monoacylglycerol with a hydrophobic tail consists of a straight acyl chain (EA, C18 lt9)) was investigated [31]. It was proposed in the literature to use ME as a model lipid for investigating the lamellar-to-nonlamellar transitions, which are of biological relevance and take place in different biological membranes imder certain circumstances [109-112]. 

Simultaneous irradiation teehniques were reported to produce a homogeneously grafted polymer of high purity. The effect of solubilizing solvent on the simultaneous y-irradiation induced graft copolymerization of... 

Table 2. Effect of solubilization and formation of membrane-like material on the values of n...

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