Deer, chronic-wasting disease

Other animal prion diseases. Outbreaks of transmissible mink encephalopathy and chronic wasting disease in captive populations of mink, mule deer and elk in certain regions of the U.S.A. have also been attributed to prion-infected foodstuffs, although the origin of prion infection is unclear [8], Epidemiological studies suggest lateral transmission as the most plausible explanation for the spread of chronic wasting disease in captive populations... [Pg.792]

Guiroy, D. C., Williams, E. S., Liberski, P. P., Wakayama, I., and Gajdusek, D. C. (1993a). Ultrastructural neuropathology of chronic wasting disease in captive mule deer. Acta Neuropathol. (Berl.) 85, 437-444. [Pg.208]

A misfolded protein appears to be the causative agent of a number of rare degenerative brain diseases in mammals. Perhaps the best known of these is mad cow disease (bovine spongiform encephalopathy, BSE), an outbreak of which made international headlines in the spring of 1996. Related diseases include kuru and Creutzfeldt-Jakob disease in humans, scrapie in sheep, and chronic wasting disease in deer and elk. These diseases are also referred to as spongiform encephalopathies, because the diseased brain frequently becomes riddled with holes (Fig. 1). Typical symptoms include dementia and loss of coordination. The diseases are fatal. [Pg.150]

Fig. 2 Clinical aspect and brain pathology. Upper picture shows a female mule deer, 3 years of age, with clinical signs of late chronic wasting disease, which include hypersalivation, emaciation and depression. Lower pictures depict amyloid plaques in the thalamus of a WTD with CWD. Left shows formalin-fixed, paraffin-embedded tissue stained with HE. Plaques are delineated with arrows. Right picture shows an immunohistochemical (IHC) staining of such amyloid plaques. Pictures kindly provided by the abatement of the late Beth Williams, University of Wyoming...

Williams ES, Young S (1980) Chronic wasting disease of captive mule deer a spongiform encephalopathy. J Wildl Dis 16 89-98... [Pg.72]

Joly DO, Samuel MD, Langenberg JA et al (2009) Surveillance to detect chronic wasting disease in white-tailed deer in Wisconsin. J Wildl Dis 45 989-997... [Pg.72]

Miller MW, Conner MM (2005) Epidemiology of chronic wasting disease in free-ranging mule deer spatial, temporal, and demographic influences on observed prevalence patterns. J Wildl Dis 41 275-290... [Pg.72]

Dulberger J, Hobbs NT, Swanson HMet al (2010) Estimating chronic wasting disease effects on mule deer recruitment and population growth. J Wildl Dis 46 1086-1095... [Pg.72]

Williams ES, Miller MW (2002) Chronic wasting disease in deer and elk in North. Am Rev Sci Tech 21 305-316... [Pg.72]

Williams ES, Young S (1993) Neuropathology of chronic wasting disease of mule deer (Odocoileus hemionus) and elk (Cervus elaphus nelsoni). Vet Pathol 30 36 -5... [Pg.72]

Liberski PP, Guiroy DC, Williams ES et al (2001) Deposition patterns of disease-associated prion protein in captive mule deer brains with chronic wasting disease. Acta Neuropathol 102 496-500... [Pg.72]

Sigurdson CJ, Spraker TR, Miller MW et al (2001) PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease. J Gen Virol 82 2327-2334... [Pg.72]

Spraker TR, O Rourke KI, Balachandran A et al (2002) Validation of monoclonal antibody F99/97.6.1 for inununohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease. J Vet Diagn Invest 14 3-7... [Pg.73]

Sigurdson CJ, Williams ES, Miller MW et al (1999) Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol 80 2757-2764... [Pg.73]

Jewell JE, Brown J, Kreeger T et al (2006) Prion protein in cardiac muscle of elk (Cervus elaphus nelsoni) and white-tailed deer (Odocoileus virginianus) infected with chronic wasting disease. J Gen Virol 87 3443-3450... [Pg.73]

Angers RC, Browning SR, Seward TS et al (2006) Prions in skeletal muscles of deer with chronic wasting disease. Science 311 1117... [Pg.73]

Mathiason CK, Hays SA, Powers J et al (2009) Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure. PLoS ONE 4 e5916... [Pg.73]

Browning SR, Mason GL, Seward T et al (2004) Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP. J Virol 78 13345-13350... [Pg.73]

Balachandran A, Harrington NP, Algire J et al (2010) Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus) early detection and late stage distribution of protease-resistant prion protein. Can Vet J 51 169-178... [Pg.75]

Fox KA, Jewell JE, Williams ES et al (2006) Patterns of PrPCWD accumulation during the course of chronic wasting disease infection in orally inoculated mule deer (Odocoileus hemionus). J Gen Virol 87 3451-3461... [Pg.75]

Wilson GA, Nakada SM, Bollinger TK et al (2009) Polymorphisms at the PRNP gene influence susceptibility to chronic wasting disease in two species of deer (Odocoileus Spp.) in western Canada. J Toxicol Environ Health A 72 1025-1029... [Pg.75]

Kelly AC, Mateus-Pinilla NE, Diffendorfer J et al (2008) Prion sequence polymorphisms and chronic wasting disease resistance in Illinois white-tailed deer (Odocoileus virginianus). Prion 2 28-36... [Pg.75]

O Rourke KI, Spraker TR, Hamburg LK et al (2004) Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibility to chronic wasting disease in white-tailed deer. J Gen Virol 85 1339-1346... [Pg.75]

Johnson C, Johnson J, Clayton M et al (2003) Prion protein gene heterogeneity in free-ranging white-tailed deer within the chronic wasting disease affected region of Wisconsin. JWildlDis 39 576-581... [Pg.75]

Keane DP, Barr DJ, Bochsler PN et al (2008) Chronic wasting disease in a Wisconsin whitetailed deer farm. J Vet Diagn Invest 20 698-703... [Pg.75]

Meade-White K, Race B, Trifilo M et al (2007) Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein. J Virol 81 4533 1539... [Pg.75]

Blanchong JA, Heisey DM, Scribner KT et al (2009) Genetic susceptibility to chronic wasting disease in free-ranging white-tailed deer complement component Clq and Pmp polymorphisms. Infect Genet Evol 9 1329-1335... [Pg.75]

Ernest HB, Hoar BR, Well JA et al (2010) Molecular genealogy tools for white-tailed deer with chronic wasting disease. Can J Vet Res 74 153-156... [Pg.75]

Hamir AN, Kunkle RA, Cutlip RC et al (2006) Transmission of chronic wasting disease of mule deer to Suffolk sheep following intracerebral inoculation. J Vet Diagn Invest 18 558-565... [Pg.76]

Trifilo MJ, Ying G, Teng C et al (2007) Chronic wasting disease of deer and elk in transgenic mice oral transmission and pathobiology. Virology 365 136—143... [Pg.76]

Hamir AN, Cutlip RC, Miller JM et al (2001) Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle. J Vet Diagn Invest 13 91-96... [Pg.76]

Hamir AN, Kunkle RA, Miller JM et al (2006) Experimental second passage of chronic wasting disease (CWD(mule deer)) agent to cattle. J Comp Pathol 134 63-69... [Pg.76]

Hamir AN, Miller JM, Kunkle RA et al (2007) Susceptibility of cattle to first-passage intracerebral inoculation with chronic wasting disease agent from white-tailed deer. Vet Pathol 44 487 193... [Pg.76]

Jennelle CS, Samuel MD, Nolden CA et al (2009) Surveillance for transmissible spongiform encephalopathy in scavengers of white-tailed deer carcasses in the chronic wasting disease area of Wisconsin. J Toxicol Environ Health A 72 1018-1024... [Pg.76]

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