Decanoic acid, absorption

CyDs are known to be able to solubilize lipophilic drugs as well as lipophilic absorption enhancers, leading to the improvement of the enhancer s efficiency. There are some reports on the use of CyDs as a candidate for a coenhancer. For example, Yanagi et al. [35] reported that CyDs may promote the potency of absorption enhancers in rectum of rabbits. Inclusion complex of decanoic acid (CIO), an absorption enhancer, with a-CyD was prepared as an additive of cefmetazole sodium suppository and rectally administered to rabbits. Plasma concentration and area under the curve (AUC) of cefmetazole sodium after rectal administration of a suppository containing ClO-a-CyD complex to rabbits increased more significantly than those with no additive. 

Yanagi, H., et al. 1991. Effect of inclusion complexation of decanoic acid with a-cyclodextrin on rectal absorption of cefmetazole sodium suppository in rabbits. Yakugaku Zasshi 111 65. 

Takahashi, K., et al. 1994. Pharmacokinetic analysis of the absorption enhancing action of decanoic acid and its derivatives in rats. Pharm Res 11 388. 

Christensen, M.S., Hoy, C.E., Becker, C.C., and Redgrave, T.G. 1995. Intestinal absorption and lymphatic transport of eicosapentaenoic, docosahexaenoic, and decanoic acids dependence on intramolecular triacylglycerols structure. Am. Clin. Nutr. 61 56-61. 

The crystal structure of the B-form of stearic acid (von Sydow, 1955) is shown in Fig. 8.27. The molecules are arranged in an orthorhombic chainpacking structure, in bilayers. The orientation of the chain-packing subcell in relation to the methyl end group planes is Oi (101) (see Section 8.1). A modified B-form was observed in 11-bromoun-decanoic acid (Larsson, 1963a) which was termed Bi. It is isomorphous with the B-form according to X-ray diffraction data, but the OH-out-of-plane vibration in the infrared absorption spectra is different. A new form of stearic acid (Holland and Nielsen, 1963), described according to infrared absorption data, appears to be the same form as Bi in 11-bromoundecanoic acid. As the first crystal... 

Transport of C-decanoic acid in porta and inferior vena cava blood during absorption in the rat. Acta physiol, scand. 34, 71 (1955b). 

Jensen, M.M., Christensen, M.S., and Hoy, C.E., Intestinal absorption of octanoic, decanoic and linoleic acids effects of triacylglycerol structure, Ann. Nutr. Metab., 38, 104, 1995. 

Bauch, A.C., Ingenbleek, Y, and Frey, A. The usefulness of dietary medium-chain triglycerides in body weight control fact or fancy J. Lipid Res. 37, 708-725, 1996. earlier, H. and Bezard, J. Electron microscope auto radiographic study of intestinal absorption of decanoic and octanoic acids in the rat. J. Cell Biol. 65, 383-397, 1975. Bloom, B., Chaikoff, I.L., and Reinhardt, WO. Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths. Am. J. Physiol. 166, 451 55, 1951. 

Several fatty acid esters of alcoholic phenothiazine derivatives, e.g., plpotiazlne (lb) undecyclenate and palmltate, fluphenazine enanthate and decanoate, and perphenazine enanthate, as well as the related thloxanthene, flupenthlxol decanoate, found clinical utility in antipsychotic maintenance therapy. These esters can afford advantages in absorption to enable attainment of high drug-levels in the CNS and to provide clinical efficacy of 2 to 4 weeks duration following a single injection. ... 

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