Dapsone Trimethoprim

DAPSONE TRIMETHOPRIM t levels of both drugs Mutual inhibition of metabolism Be aware - watch for t incidence of side-effects... [Pg.552]

Lee BL, Medina 1, Benowitz NL, Jacob P, 3rd, Wofsy CB, Mills Jt. Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Evidence of drug interactions. Annals of internal medicine. 1989 Apr 15 110(8) 606-n. [Pg.378]

Sulfonamides Trimethoprim Dapsone Isoniazid Modification of energy metabolism... [Pg.151]

Fig. 5.16 A, some sulphonamides B, prontosil rabram C, unsubstituted diaminobenzylpyrimidines D, trimethoprim E, tetroxoprim F, dapsone.

Antibiotic resistance profiles of the bacterial communities reflected the effects of deforestation and the land degradation (Fig. 2). The degradation was significant (p=0.05) as a source of variation for the numbers of soil bacterial cells resistant to lasalocid, penicillin, spectinomycin and trimethoprim, and marginally significant (0.50 Significant differences between two average values were observed for some antibiotics. When compared with the BG soil bacterial community, the DEF soil bacterial community had more bacterial cells resistant to dapson, kanamycin, lasalocid, nafcillin, penicillin, spectinomycin, streptomycin and trimethoprim. [Pg.326]

Drugs that may affect zidovudine include acetaminophen, atovaquone, bone marrow suppressive/cytotoxic agents (eg, adriamycin, dapsone), clarithromycin, doxorubicin, fluconazole, ganciclovir, methadone, nelfinavir/ritonavir, phenytoin, probenecid, ribavirin, rifamycins, stavudine, trimethoprim, and valproic acid. [Pg.1870]

VI.a.2.4. Diaminopyrimidines. Pyrimethamine is a dihydrofolate reductase inhibitor, like the biguanides, and is structurally related to trimethoprim. It is seldom used alone. Pyrimethamine in fixed combinations with dapsone or sulfadoxine is used for treatment and prophylaxis of chloroquine-resistant falciparum malaria. The synergistic activities of pyrimethamine and sulfonamides are similar to those of trimethoprim/sulfonamide combinations. Resistant strains of Plasmodium falciparum have appeared world wide. Prophylaxis against falciparum... [Pg.426]

Dapsone and pyrimethamine should be used in patients that cannot tolerate sulfamethoxazole/trimethoprim with a CD4 count less than... [Pg.562]

Trimethoprim has been reported to decrease the therapeutic effect of cyclosporine with a concomitant increased risk of nephrotoxicity. Increased levels of dapsone, warfarin, methotrexate, zidovudine, and sul-fonylureas may occur when given together with trimethoprim dosages of these drugs should be modified and the patient monitored accordingly. [Pg.519]

Dapsone, combined with other antUeprosy agents like rifampin and clofazimine, is used in the treatment of both multibacillary and paucibacillary M. leprae infections. Dapsone is also used in the treatment and prevention of Pneumocystis carinii pneumonia in AIDS patients who are allergic to or intolerant of trimethoprim-sulfamethoxazole. [Pg.564]

The answers are 484-k, 483-j. (Hardman, pp 1061—1062, 1682-1683.) Sulfonamides can cause acute hemolytic anemia. In some patients it may be related to a sensitization phenomenon, and in other patients the hemolysis is due to a glucose-6-phosphate dehydrogenase deficiency. Sulfamethoxazole alone or in combination with trimethoprim is used to treat UTIs. The sulfonamide sulfasalazine is employed in the treatment of ulcerative colitis. Dapsone, a drug that is used in the treatment of leprosy, and primaquine, an antimalarial agent, can produce hemolysis, particularly in patients with a glucose-6-phosphate dehydrogenase deficiency. [Pg.270]

Pneumocystis jiroveci pneumonia (PCP) High-risk patients (eg, AIDS, leukemia, transplant) Trimethoprim-sulfamethoxazole, dapsone, or atovaquone Excellent... [Pg.1114]

Toxoplasmosis Lymph nodes many organs and tissues Pyrimethamine-sulfadiazine [see antimalarial drugs] other antibacterials [clindamycin] Trimethoprim-sulfamethoxazole another agent [azithromycin, clarithromycin, atovaquone, or dapsone]... [Pg.552]

Antibiotics with antiprotozoal activity are not included in this chapter. These include clindamycin, co-trimoxazole-trimethoprim, dapsone, doxycycline and... [Pg.509]

This section consists of antiprotozoal drugs. Note that antimalarials are also antiprotozoals but have been described in a separate section Antibiotics with antiprotozoal activity are not included in this chapter. These include clindamycin, co-trimoxazole/trimethoprim, dapsone, doxycydine and metronidazole ... [Pg.592]

Holtzer CD, Flaherty JF Jr, Coleman RL. Cross-reactivity in HIV-infected patients switched from trimethoprim-sulfamethoxazole to dapsone. Pharmacotherapy 1998 18(4) 831-5. [Pg.3523]

Lee BL, Safrin S, Makrides V, Gambertogho JG. Zidovudine, trimethoprim, and dapsone pharmacokinetic interactions in patients with human immunodeficiency virus infection. Antimicrob Agents Chemother 1996 40(5) 1231-6. [Pg.3524]

Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones... [Pg.353]

Dapsone in combination with trimethoprim is also used for the treatment of mild to moderate first episodes of TCP, or alone for PCP prophylaxis [115, 198]. The most frequent adverse events are dose related metheglobinemia and hemolytic anemia. Since multi-drug therapy began to be used in leprosy patients, an increasing number of a rare, idiosyncratic reaction with multiorgan involvement... [Pg.367]

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