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Cytoxan - Cyclophosphamide

AC, Adriamycin (doxorubicin), Cytoxan (cyclophosphamide) CAF, Cytoxan (cyclophosphamide), Adriamycin (doxorubicin), 5-fluorouracil CEF, cyclophosphamide, epirubicin, 5-fluorouracil CMF, cyclophosphamide, methotrexate, 5-flourouracil FAC, 5-fluorouracil, Adriamycin (doxorubicin), cyclophosphamide FEC, 5-fluorouracil, epirubicin, cyclophosphamide TAC, Taxol (paclitaxel), Adriamycin (doxorubicin), cyclophosphamide. [Pg.697]

TEM (triethylenemelamine) Myleran or Busulfan (methanesulfonic acid, tetramethylene ester), antimitotic drugs such as Dichloren (me-chlorethamine hydrochloride) and Cytoxan (cyclophosphamide). X-rays, and steroid therapy show different effects without consistent results. The question must be further investigated. [Pg.80]

Cytoxan - cyclophosphamide Mustargen - mechlorethamine Thioplex - thiotepa... [Pg.395]

The early research on Herceptin demonstrated the importance of correlating combinations of drugs with genomics-based treatment. Women with metastatic cancer got better results when they took Herceptin together with the chemotherapy drugs Taxol or Adriamycin (doxorubicin) plus Cytoxan (cyclophosphamide). These drug combinations reduced the tumors of 45% of women treated, while only 29% who received chemotherapy alone had a similar response. When Herceptin plus chemotherapy was used, it boosted survival, by an average of 5 months. [Pg.183]

Fig. 9.14a, b. Bladder carcinoma treated with CISCA. a Pretreatment intravenous pyelography (IVP). Transitional cell carcinoma involving the bladder wall on the right, b Posttreatment IVP. After CISCA therapy, lA infusion with cisplatin and IV Cytoxan (cyclophosphamide) and Adriamycin (doxorubicin), revealed a complete response with a disappearance of the bladder tumor... [Pg.208]

Acid Ester Diamide Endoxan Cytoxan. Cyclophosphamide produces mainly chromatid-type aberrations in small mammals and in human lymphocytes. 102-108) it also induces dominant lethals in premeiotic and in postmeiotic male germ cells. 8 09,110)... [Pg.43]

Cyclophosphamide is nsed both intravenously and orally. It is nsed for chronic lymphatic lenkemia, Hodgkin s disease, Burkitt s lymphoma, multiple myeloma, and cancer of the breast, neck, ovaries, and so on. Synonyms of this drug are endoxan, cyclostin, Cytoxan, cyclophosphane, and others. [Pg.398]

NITROGEN MUSTARDS Chlorambucil (Leuk an) Cyclophosphamide (Cytoxan, Neosar)... [Pg.37]

Cyclophosphamide (Cytoxan) is the most versatile and useful of the nitrogen mustards. Preclinical testing showed it to have a favorable therapeutic index and to possess the broadest spectrum of antitumor activity of all alkylating agents. As with the other nitrogen mustards, cyclophosphamide administration results in the formation of cross-links within DNA due to a reaction of the two chloroethyl moieties of cyclophosphamide with adjacent nucleotide bases. Cyclophosphamide must be activated metabofically by microsomal enzymes of the cytochrome P450 system before ionization of the chloride atoms and formation of the cyclic ethylenimmonium ion can occur. The metabolites phosphoramide mustard and acrolein are thought to be the ultimate active cytotoxic moiety derived from cyclophosphamide. [Pg.640]

Cyclophosphamide Cytoxan Oral 1.5-2 mg/kg body weight per day can be increased to a maximum daily dose of 3 mg/kg body weight. Long-term use is limited because of potential for carcinogenicity. [Pg.223]

Cyclophosphamide Cytoxan, Neosar Acute and chronic lymphocytic leukemia acute and chronic myelocytic leukemia carcinoma of ovary, breast Hodgkin disease non-Hodgkin lymphomas multiple myeloma Blood disorders (anemia, leukopenia, thrombocytopenia] Gl distress (nausea, vomiting, loss of appetite] bladder irritation hair loss car-diotoxicity pulmonary toxicity... [Pg.570]

CHOP Cyclophosphamide (Cytoxan), doxorubicin, vincristine (Oncovin), prednisone Non-Hodgkin lymphoma... [Pg.583]

CMF Cyclophosphamide (Cytoxan), methotrexate, 5-fluorouracil Breast cancer... [Pg.583]

FAC 5-Fluorouracil, doxorubicin (Adriamycin), cyclophosphamide (Cytoxan) Breast cancer... [Pg.583]

Cyclophosphamide Cytoxan, Neosar Bone marrow, other organ transplants Rheumatoid arthritis, multiple sclerosis, SLE, dermato-myositis, glomerulonephritis, hematologic disorders... [Pg.594]

Clinical Use. Cyclophosphamide (Cytoxan, Neosar) is an anticancer alkylating agent that is commonly used in a variety of neoplastic disorders (see Chapter 36). This drug may also be helpful in suppressing the immune response in certain autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.12 43 High doses of cyclophosphamide are also used to prevent tissue rejection in patients receiving bone marrow transplants and other organ transplants. [Pg.595]

See other pages where Cytoxan - Cyclophosphamide is mentioned: [Pg.1688]    [Pg.355]    [Pg.356]    [Pg.90]    [Pg.646]    [Pg.1175]    [Pg.1688]    [Pg.1688]    [Pg.1389]    [Pg.1343]    [Pg.1387]    [Pg.1688]    [Pg.355]    [Pg.356]    [Pg.90]    [Pg.646]    [Pg.1175]    [Pg.1688]    [Pg.1688]    [Pg.1389]    [Pg.1343]    [Pg.1387]    [Pg.584]    [Pg.183]    [Pg.185]    [Pg.131]    [Pg.4]    [Pg.121]    [Pg.32]    [Pg.437]    [Pg.639]    [Pg.506]    [Pg.506]    [Pg.121]    [Pg.356]    [Pg.219]    [Pg.228]   


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