Cyclophosphamide ‘Cytoxan’, ‘Endoxan

Cyclophosphamide (Cytoxan and Endoxan) is used in the treatment of Hodgkin s disease, lymphosarcoma, and other lymphomas. It is employed as a secondary drug in patients with acute leukemia and in combination with doxorubicin in women with breast cancer. A drug combination effective in the treatment of breast cancer is cyclophosphamide, methotrexate, fluorouracil, and prednisone (CMFP). Cyclophosphamide is also an immunosuppressive agent. The toxicity of cyclophosphamide causes alopecia, bone marrow depression, nausea and vomiting, and hemorrhagic cystitis. 

Cyclophosphamide Cytoxan Neosar Cytophosphan Endoxan Clafen Oxazaphosphorine alkylating agent ( Nitrogen mustard ) mp 143 °C Treatment of lymphomas leukemias, multiple myeloma, and other cancers n O. NH C1 C1... 

Cyclophosphamide is nsed both intravenously and orally. It is nsed for chronic lymphatic lenkemia, Hodgkin s disease, Burkitt s lymphoma, multiple myeloma, and cancer of the breast, neck, ovaries, and so on. Synonyms of this drug are endoxan, cyclostin, Cytoxan, cyclophosphane, and others. 

Acid Ester Diamide Endoxan Cytoxan. Cyclophosphamide produces mainly chromatid-type aberrations in small mammals and in human lymphocytes. 102-108) it also induces dominant lethals in premeiotic and in postmeiotic male germ cells. 8 09,110)... 

Nitromin is an example of chemical change as a step in the activation of a drug which, imtil activation occurs, exists in a stable and beneficial depot (a principle discussed in Section 3.5). Cyclophosphamide (3.28) ( Endoxan , Cytoxan ) is another pro-drug of this kind. This substance cannot form an aziridiniiun cation, like (/2. j2), until the phosphonolactone ring is opened, as happens in the liver. It can be given orally, and produces very good... 

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