Acute renal failure cyclosporine nephrotox

The beneficial effect of curcumin in preventing the acute renal failure and related oxidative stress caused by chronic administration of cyclosporine was examined in rats (Tirkey et al. 2005). Curciunin administered concurrently with for 21 days effectively attenuated cyclosporine induced nephrotoxicity through its antioxidant activity as revealed by markedly countered elevated levels of TEARS, attenuated renal dysfunction, and increased levels of antioxidant enzymes. 

Nephrotoxicity associated with amphotericin B administration in humans is dose related and it may be severe and result in acute renal failure. The incidence of acute renal failure may be as high as 49 to 65%. It is accompanied by an increase in serum creatinine. Mortality may be high and is increased by the co-administration of other nephrotoxic drugs. Risk factors include cumulative dose, abnormal baseline renal function, concomitant nephrotoxic drugs such as cyclosporin, and infusion rates. However, rapid infusion rates are also associated with severe hyperkalaemia and potentially fatal arrhythmias. " In one case, a woman given 5mg/kgbw/day amphotericin B instead of the... 

Nephrotoxicity is a common toxicity and significant problem associated with the use of cyclosporine in humans. Three types of nephrotoxicity have been observed in patients receiving cyclosporine (1) an acute, reversible renal failure (2) acute vasculopathy or thrombotic microangiopathy and (3) chronic renal failure with interstitial fibrosis that may not be reversible. 

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