Cyclofenil

Other compounds of this general class which have been found to have antiestrogenic properties include the cytochrome P-450 inhibitor, SKF 525A P02-33-0](Sl) (24) JV, JV-diethyl-2-[(4-phenylmethyl)phenoxy]ethanamine [98774-23-3] (DPPE)(58) (42) /-Butylphenoxyethyl diethylamine [57586-10-4] (BPEA)(59) (43) and cyclofenil [110042-18-7] (60, R = C H ) (24) analogues. 

Phethenylate sodium Ammonium chloride Cyclofenil Methionine Ammonium sulfate Aminobenzoic acid Fibrinolysin Ammonium sulfamate Cyclamate calcium Ammonium thiocyanate Acetazolamide Clonidine HCl Tolonidine nitrate 2oxazo lamina d-Amphetamine Tanphetamin Ampicillin Mezlocillin Talampicillin... 

Timolol maleate a-Bromoacetophenone Nomifensine maleate Bromoacetyl bromide Bromazepam Cephapirin sodium Clonazepam Flunitrazepam 5-Bromoacetyl salicylamide Labetalol HCI m-Bromoanisole Tramadol HCI p-Bromoanisole Cyclofenil Bromobenzene... 

C10H12O4 65870-46- ) see Paclitaxe] 4,4 -dihydroxybenzhydrylidenecyclohexane (C19H20O2 5189-40-2) see Cyclofenil 2-(4,4 -dihydroxybenzhydryl)pyridine... 

Aromatase inhibitors (including anastrozole, letrozole, aminoglutethimide, exemestane, formestane, testolactone), selective estrogen receptor modulators—SERMs (including raloxifene, tamoxifen, toremifene), clomiphene, cyclofenil, fulvestrant Diuretics, amiloride, bumetanide, canrenone, chlorthalidone, etacrynic acid, furosemide, indapamide, metolazone, spironolactone, thiazides, triamterene... 

Ondogyne Cyclofenil Pectokay Kaolin + Pectin (= atta-... 

Cyclofenil is a weak non-steroidal estrogen related to diethylstilbestrol. For a number of years it was used for inducing ovulation, but has lost favor more recently there have been studies of its possible effects in Raynaud s phenomenon secondary to scleroderma (1). 

Up to 2% of patients taking cyclofenil complain of nausea, vomiting, hot flushes, or headache. Mild abdominal pain has been reported in up to 18%, ovarian enlargement without cysts in 3%, and galactorrhea in 4%. There have been a few case reports of hemolytic anemia (SED-12,1034) (2). 

Cyclofenil can cause reversible mild cholestatic jaundice. The authors of a review of 30 patients with hepatic reactions to cyclofenil concluded that liver derangement due to cyclofenil is probably related to metabolic hypersusceptibility rather than to a direct toxic effect (3). There is a surprising lack of such reports from countries where cyclofenil was widely used in France, at least, the number of cases of hepatitis occurring is known to have been much greater than that reported in print, and the drug was abandoned in that country in 1988. 

Pope J, Fenlon D, Thompson A, Shea B, Furst D, Wells G, Silman A. Cyclofenil for Raynaud s phenomenon in progressive systemic sclerosis. Cochrane Database Syst Rev 2000 (2) CD000955. 

Wollheim FA, Ljunggren HO, Blom-Bulow B. Hemolytic anemia during cyclofenil treatment of scleroderma. Acta Med Scand 1981 210(5) 429-30. 

Schmidt-Elmendorff H, Kammerling R. Vergleichende kli-nische Untersuchungen von Clomiphen. Cyclofenil und Epimestrol. [Comparative clinical studies on clomiphen, cyclofenil and epimestrol.] Geburtshilfe Frauenheilkd 1977 37(6) 531-41. 

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