Phethenylate Sodium

Chemical Name 5-Phenyl-5-(2-thienyl)-2,4-imidazolidinedione monosodium salt Common Name — 

Phenyl-(2-thienyl)ketone Potassium cyanide Ammonium carbonate 

The 5-phenyl-5-(2-thienyl)hydantoin is prepared by heating a mixture of 5.64 g (0.03 mol) of phenyl-(2-thienyl)ketone, 3.25 g (0.03 mol) of potassium cyanide and 10.2 g (0.09 mol) of ammonium carbonate in 75 cc of 50% ethanol for 28 hours at a temperature of about 110°C. An additional 3.25 g of potassium cyanide and 3 g of ammonium carbonate are added and the mixture heated for 24 hours at about 110°C. 

The reaction mixture is removed and about half of the liquid evaporated, an oil separating during the process. The mixture is acidified with concentrated hydrochloric acid and extracted with two 100 cc portions of ether. The extracts, which contain the 5-phenyl-5-(2-thienyDhydantoin, are combined and the combined ether extracts are shaken with two 25 cc portions of 5% potassium hydroxide solution. The alkaline solution, which dissolves the 5-phenyl-5-(2-thienyl)hydantoin to form the potassium salt thereof, isacidifed with hydrochloric acid and heated to expel ether. 

By the process of purification, 4.3 g of 5-phenyl-5-(2-thienyl)hydantoin is obtained,and from the ether layer, 2.2 g of unreacted ketone. The yield of the 5-phenyl-5-(2-thienyl)hy-dantoin is about 56%. The melting point of the purified 5-phenyl-5-(2-thienyl)hydantoin is about 256°C to 257°C. 

Phenyl-(2-thienyOketone Potassium cyanide Ammonium carbonate 

Phenyl-(2-th lenyDketone Potassium cyanide Ammonium carbonate 

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Phethenylate sodium Ammonium chloride Cyclofenil Methionine Ammonium sulfate Aminobenzoic acid Fibrinolysin Ammonium sulfamate Cyclamate calcium Ammonium thiocyanate Acetazolamide Clonidine HCl Tolonidine nitrate 2oxazo lamina d-Amphetamine Tanphetamin Ampicillin Mezlocillin Talampicillin... 

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