Nomifensine maleate

Chemical Name 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyi-isoquinoline Common Name — 

A solution of N-(2-aminobenzyl)-1-phenyl-2-metbylaminoethanol-1 was prepared by the reaction of a-bromo-acetophenone and (2-nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-iso-quinoline. The base is reacted with maleic acid to give the maleate melting point of the maleate 199° to 201°C (from ethanol). 

Farbwerke Hoechst AG, Germany British Patent 1,164,192 September 17,1969 Ehrhart, G., Schmitt, K Hoffmann, Land Ott, H. U.S. Patent 3,577,424 May 4, 1971 assigned to Farbwerke Hoechst AG. 

Alival Marital Alival Psicronizer Marital Neurolene Nomival 

Q-8romoaoetophenone (2-Nitrobenzy I )methy lamina Sulfuric acid 

Trade Name Manufacturer Country Year Introduced 

Alival Merital Alival Psicronizer Merital Neurolene Nomival 

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Timolol maleate a-Bromoacetophenone Nomifensine maleate Bromoacetyl bromide Bromazepam Cephapirin sodium Clonazepam Flunitrazepam 5-Bromoacetyl salicylamide Labetalol HCI m-Bromoanisole Tramadol HCI p-Bromoanisole Cyclofenil Bromobenzene... 

Infra-red Spectrum. Principal peaks at wavenumbers 1580, 877, 741,1000, 708, 775 (nomifensine maleate). 

Butaperazine Maleate Clobetasol Propionate Dimetridazole Hydrochloride Nomifensine Maleate... 

Timolol maleate a-Bromoacetophenone Nomifensine maleate Bromoacetyl bromide Bromazepam Cephapirin sodium Clonazepam Flunitrazepam... 

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