Cycling regulation

Conformational changes in a protein kinase are important for cell cycle regulation... 

The ankyrin repeat motif is one of the most common protein-protein interaction domains. Ankyrin repeats are modules of about 33 amino acids repeated in tandem. They are found in a large number of proteins with diverse cellular functions such as transcriptional regulators, signal transducers, cell-cycle regulators, and cytoskeletal proteins. 

Cell Cycle Control. Figure 1 Cell cycle regulation by Cyclin dependent kinases (CDKs). Different cyclins bound to different CDKs promote the transition from one cell cycle phase into another. CDK-dependent phosphorylation of Rb is required to release active E2F transcription factors, which promotes entry into S phase. 

Cell Cycle Regulation by Ubiqnitin-Mediated Protein Degradation... 

In concordance with the central role of ubiquitin modification in multiple cellular functions perturbations of this system are associated with a variety of diseases. Defects in the control of cell cycle regulators by the ubiquitin proteasome system are connected to cancer progression and many E3 ligases were originally identified as oncogenes. 

Genes implicated in cell signaling and cell cycle regulation (for examples see text)... 

Marlowe, J.L. and Puga, A. (2005). Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. Journal of Cellular Biochemistry 96, 1174-1184. 

Select regulatory molecules (eg, G proteins, cell cycle regulators) 988 (3.2%)... 

Baryshnikova OK, Sykes BD (2006) Backbone dynamics of SDF-lalpha determined by NMR interpretation in the presence of monomer-dimer equilibrium. Protein Sci 15 2568-2578 Becker EB, Bonni A (2004) Cell cycle regulation of neuronal apoptosis in development and disease. Prog Neurobiol 72 1-25... 

Garcia-Garcia, F and Drucker-Colin, R (1999) Endogenous and exogenous factors on sleep-wake cycle regulation. Prog. Neurobiol. 58 297-314. 

As to be expected, the most common goal of contraception is the prevention of pregnancy. However, some patients may use contraceptive methods for other benefits, such as menstrual cycle regulation, reduction of premenstrual symptoms, or treatment of acne. 

Ben-David, Y., Letwin, K., Tannock, L., Bernstein, A., and Pawson, T. (1991). A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 10 317-325. 

Ducommun, B., Draetta, P., Young, P and Beach, D. (1990). Fission yeast cdc25 is a cell-cycle regulated protein. Bichem. Biophys. Res. Commun. 167 301-307. 

Fosburg, S. L., and Nurse, P. (1991). Cell cycle regulation in the yeasts Saccharomyces cerevisiae and Schizosaccaromycespombe. Annu, Rev. Cell Biol. 7 227-256. 

Gu, Y., Rosenblatt, J., and Morgan, D. O. (1992). Cell cycle regulation of CDK2 activity by phosphorylation of Thrl61 and Tyrl5. EMBO J. 11 3995-4005. 

Hirai, T., Yamashita, M., Yoshikuni, M., Tokumoto, T., Kajiura, H., Sakai, N., and Nagahama, Y. (1992). Isolation and characterization of goldfish cdk2, a cognate variant of the cell cycle regulator cdc2. Dev. Biol. 152 113-120. 

Osmani, A. H., McGuire, S. L., and Osmani, S. A. (1991). Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. EMBO J. 67 283-291. 

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