Subacute cutaneous lupus erythematosus

Bonsmann, G. et al, Terbinafine-induced subacute cutaneous lupus erythematosus, J. Amer. Acad. Dermatol., 44, 925, 2001. 

Subacute cutaneous lupus erythematosus has been attributed to anastrozole (33). 

Trancart M, Cavailhes A, Balme B, Skowron F. Anastrozole-induced subacute cutaneous lupus erythematosus. Br J Dermatol 2008 158(3) 628-9. 

Crowson AN, Magro CM. Lichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated with antihistamine therapy. J Cutan Pathol 1999 26(2) 95-9. 

Toll A, Campo-Pisa P, Gonzalez-Castro J, Campo-Voegeli A, Azon A, Iranzo P, Lecha M, Herrero C. Subacute cutaneous lupus erythematosus associated with cinnarizine and thiethylperazine therapy. Lupus 1998 7(5) 364-6. 

Photo-induced annular or papulosquamous eruptions due to subacute cutaneous lupus erythematosus with positive antinuclear, anti-Ro, and anti-La antibodies have been reported with verapamil, nifedipine, and diltiazem (113). 

Crowson AN, Magro CM. Subacute cutaneous lupus erythematosus arising in the setting of calcium channel blocker therapy. Hum Pathol 1997 28(l) 67-73. 

A 32-year-old woman developed subacute cutaneous lupus erythematosus after exposure to the sun while taking cinnarizine and thiethylperazine for vertigo (7). A similar eruption had occurred 10 years before, after exposure to the sun, while she was taking cinnarizine only. The problem did not occur when she was not taking the drug. 

Although patients treated with etanercept commonly develop new antinuclear antibodies or anti-double-stranded DNA antibodies, there were no reports of cutaneous or systemic lupus erythematosus in early clinical trials. However, since then, at least eight cases have been reported, including five patients with a lupus-like syndrome, two with acute discoid lupus, and one with subacute cutaneous lupus erythematosus (26-29). All were women and they developed their first symptoms 6 weeks to 14 months after the first injection of etanercept. Antinuclear and/or anti-DNA antibodies were positive in most of them. Etanercept was withdrawn in all patients with features of systemic lupus erythematosus, and the symptoms resolved within 2-8 weeks. The skin lesions also improved with local glucocorticoids, despite continued etanercept treatment in two patients with discoid lupus or subacute cutaneous lupus erythematosus. This suggests that etanercept-induced autoantibodies are sometimes associated with clinical autoimmune disease. 

Bleumink GS, ter Borg EJ, Ramselaar CG, Ch Strieker BH. Etanercept-induced subacute cutaneous lupus erythematosus. Rheumatology (Oxford) 2001 40(11) 1317-19. 

Miyagawa S, Okuchi T, Shiomi Y, Sakamoto K. Subacute cutaneous lupus erythematosus lesions precipitated by griseofulvin. J Am Acad Dermatol 1989 21(2 Pt 2) 343-6. Erratum in J Am Acad Dermatol 1990 22(2 Pt 2) 345. 

Ross S, Ormerod AD, Roberts C, Dwyer C, Herriot R. Subacute cutaneous lupus erythematosus associated with phenytoin. Clin Exp Dermatol 2002 27(6) 474-6. 

Exacerbation of lupus erythematosus has been reported during terbinafine therapy (55-57,61). Of 21 consecutive patients with subacute cutaneous lupus erythematosus who attended an outpatient dermatology department in Germany during 1 year, 4 had terbinafine-associated disease (62). In addition to high titers of antinuclear antibodies with a homogeneous pattern, anti-Ro(SS-A) antibodies were present in three of the four women, anti-La(SS-B) antibodies were also found. All the... 

Bonsmann G, Schiller M, Luger TA, Slander S. Terbmafme-induced subacute cutaneous lupus erythematosus. J Am Acad Dermatol 2001 44(6) 925-31. 

Parodi A, Romagnoli M, Rebora A. Subacute cutaneous lupus erythematosus-hke eruption caused by hydrochlorothiazide. Photodermatol 1989 6(2) 100-2. 

Reed BR, Huff JC, Jones SK, Orton PW, Ix e LA, Norris DA. Subacute cutaneous lupus erythematosus associated with hydrochlorothiazide therapy. Ann Intern Med 1985 103(1) 49-51. 

Manifestations in the skin are nearly as common as those involving the musculoskeletal system. " The most well known of these is the butterfly rash, which occurs over the bridge of the nose and the malar eminences. The classic butterfly rash is seen in approximately one-half of patients and often is observed after sun exposure. In fact, photosensitivity is common to many SLE patients who present with cutaneous manifestations. Skin lesions characteristic of discoid lupus occur in 10% to 20% of patients with SLE and may occur without other clinical or serologic evidence of lupus. Some individuals are said to develop subacute cutaneous lupus erythematosus, the nature of whose lesions falls between discoid (one type of chronic... 

Photosensitivity. Skin reddening due to an abnormal reaction to sunlight. A characteristic symptom of systemic autoimmune diseases (e.g. systemic lupus erythematosus, mixed connective tissue disease), cutaneous and subacute cutaneous lupus erythematosus. 

Subacute cutaneous lupus erythematosus (SCLE). A chronic remitting form of dermatitis characterized by severe photosensitivity and Ro/SS-A and La/SS-B autoantibodies. 

Toms-Whittle LM, John LH, Buckley DA. Drug-induced subacute cutaneous lupus erythematosus associated with omeprazole. Clin Exp Dermatol 2011 36 281-3. 

Subacute cutaneous lupus erythematosus occurred after the use of interferon alfa in the treatment of metastatic renal cell carcinoma [12 ]. 

Lee HY, Pang SM. Subacute cutaneous lupus erythematosus after immunotherapy for renal-cell carcinoma the case for interferon-alpha. Clin Exp Dermatol 2010 35(5) 491-2. 

A 73-year-old woman developed weakness and ei hematous plaques on the trunk and limbs after taking propafenone for 2 months. She had a neutropenia with a predominance of immature cells in the bone marrow. Skin biopsy was compatible with subacute cutaneous lupus erythematosus. After withdrawal of all drugs there was complete clinical and analytical recovery. Her medications were then sequentially re-introduced, with the exception of propafenone. After 6 months she remained asymptomatic. 

Kasperkiewicz M, Anemtiller W, Ange-lova-Fischer I, Rose C, Zillikens D, Fischer TW. Subacute cutaneous lupus erythematosus associated with terbinafine. Chn Exp Dermatol 2009 34 e403. ... 

Subacute cutaneous lupus erythematosus Although SSRls have been associated with adverse cutaneous reactions secondary to photosensitivity, subacute cutaneous lupus erythematosus (SCLE) has not been previously described [39 ]. 

Yang EIM, Lee WK, Chang SW, Chiu NM, Huang JH. Escitalopram-induced word finding difficulty. Gen Hosp Psychiatry 2013 35(1) 103 e5-6. Rohrs S, Geiser F, Conrad R. Citalopram-induced subacute cutaneous lupus erythematosus - first case and review concerning photosensitivity in selective serotonin reuptake inhibitors. Gen Hosp Psychiatry 2012 34(5) 541-5. 

Skin A 73-year-old woman, with a 30-year history of subacute cutaneous lupus erythematosus presented with an acute flare of her disease, characterised by erythematous, annular and scaly plaques over her trunk and limbs. She had been in remission, and off-treatment for 4 years. One week before, she had been started on therapy with naproxen for arthritis in combination with omeprazole for gastrointestinal protection. Both drugs were discontinued by the patient because of her acute disease flare. Her symptoms resolved after 2 months of oral treatment with prednisolone. Three months later flie patient presented again with another sudden-onset flare of subacute cutaneous lupus erythematosus involving her face, trunk, arms, buttocks and thighs. Two weeks earlier, she had been restarted on naproxen plus omeprazole. On this occasion, the patient was treated with oral prednisolone (40 mg) and hydroxychloroquine (200 mg) twice daily. Mycophenolate mofetil (500 mg twice daily) was introduced 1 week later because of her further deterioration. In the meantime, omeprazole was discontinued. These actions were followed by a dramatic improvement of the subacute cutaneous lupus erythematosus within 5 weeks [53 ]. 

Wee JS, Natkunar ah J, Marsden RA. A difficult diagnosis drug-induced subacute cutaneous lupus erythematosus (SGLE) triggered by omeprazole in a patient with pre-existing idiopathic SCLE. CUn Exp Dermatol 2012 37 445-6. 

Skin DOX chemotherapy has been associated with the development of subacute cutaneous lupus erythematosus (SCLE). This has been observed with the combination of cyclophosphamide and DOX. In a case study SCLE was observed in a patient with metastatic breast cancer treated with DOX alone After her second cycle of chemotherapy a pruritic facial rash developed and subsequently worsened with two further cycles of DOX. Treatment was initiated and DOX chemotherapy was discontinued and the SCLE resolved after 5 weeks. 

Darken, M. and McBumey, E., Subacute cutaneous lupus erythematosus-like drug eruption due to combination diuretic hydrochloro-thiazide and triamterene, /. Am. Acad. Dermatol, 18,38,1988. 

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