Subacute cutaneous lupus erythematosus SCLE

Subacute cutaneous lupus erythematosus (SCLE). A chronic remitting form of dermatitis characterized by severe photosensitivity and Ro/SS-A and La/SS-B autoantibodies. 

Subacute cutaneous lupus erythematosus Although SSRls have been associated with adverse cutaneous reactions secondary to photosensitivity, subacute cutaneous lupus erythematosus (SCLE) has not been previously described [39 ]. 

Skin DOX chemotherapy has been associated with the development of subacute cutaneous lupus erythematosus (SCLE). This has been observed with the combination of cyclophosphamide and DOX. In a case study SCLE was observed in a patient with metastatic breast cancer treated with DOX alone After her second cycle of chemotherapy a pruritic facial rash developed and subsequently worsened with two further cycles of DOX. Treatment was initiated and DOX chemotherapy was discontinued and the SCLE resolved after 5 weeks. 

Wee JS, Natkunar ah J, Marsden RA. A difficult diagnosis drug-induced subacute cutaneous lupus erythematosus (SGLE) triggered by omeprazole in a patient with pre-existing idiopathic SCLE. CUn Exp Dermatol 2012 37 445-6. 

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