Thiazide, hydrochloro

Methyldopa (Aldomet) and methyl dopa-hydrochloro thiazide (Aldoril) May cause bradycardia, and exacerbate depression in elderly patients. High... 

Dorevitch A, Baruch E. Lithium toxicity induced by combined amiloride HCl-hydrochloro-thiazide administration. Am J Psychiatry (1986) 143, 257-8. 

Hydrochloro- thiazide Merck 10.1 492 NaCI-transport inhibitor High blood pressure... 

Mixed surfactant mobile phases can be useful to improve the selectivity required in difficult separations [18]. Although hydrochloro thiazide was well separated from the urine matrix with a Brij-35 mobile phase, no resolution could be achieved between this diuretic and its hydrolysis product 5-chloro-2,4-disulfamoylaniline, which is formed in aqueous solution upon standing at room temperature. In contrast, baseline separation was obtained between the two compounds with SDS mobile phases. However, SDS eluents did not provide separation of the diuretic from the prominent peak in urine. The optimized mobile phase contained 0.004 M SDS (below its cmc), in addition to 0.02 M Brij-35. The small amount of SDS was added to obtain resolution between the diuretic and its hydrolysis product, without compromising the separation of the drug from the urine background. 

Darken, M. and McBumey, E., Subacute cutaneous lupus erythematosus-like drug eruption due to combination diuretic hydrochloro-thiazide and triamterene, /. Am. Acad. Dermatol, 18,38,1988. 

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