Curcumin sources

Two colorimetric methods are recommended for boron analysis. One is the curcumin method, where the sample is acidified and evaporated after addition of curcumin reagent. A red product called rosocyanine remains it is dissolved in 95 wt % ethanol and measured photometrically. Nitrate concentrations >20 mg/L interfere with this method. Another colorimetric method is based upon the reaction between boron and carminic acid in concentrated sulfuric acid to form a bluish-red or blue product. Boron concentrations can also be deterrnined by atomic absorption spectroscopy with a nitrous oxide—acetjiene flame or graphite furnace. Atomic emission with an argon plasma source can also be used for boron measurement. 

Curcumin (16) is a polyphenolic compound derived naturally from the plant Curcuma longa also known as turmeric (Haldi). It is the primary source of the distinctive bright yellow color of the spice commonly used in the preparation of curries. Originating in India, turmeric was probably cultivated initially as a dye, and later used in cosmetics and foods. It has... 

Could a truly imstable product be labeled stable as a result of testing using an inappropriate source In theory this is possible, especially with Option 2, if the compound or degradation products that sensitize the reaction absorb mainly in the "gap" (380-420 nm), e.g., curcumin or bilirubin. As mentioned above, it is important to combine the results with knowledge already obtained from other tests before labeling and packaging decisions are made. 

Curcumin, as well as compounds 40-43 were also isolated from C. xanthorrhiza by Uehara et a/. (29), who obtained from this source also two new compounds, the optically active diol (5,5)-45 and the racemic diketoalcohol 46. While formation of 45 can be envisaged by reduction of hexahydrocurcumin, racemic 46 might have been the result of addition of water onto the double bond of curcumin. Masuda and his coworkers reported in 1992 the isolation of an unsymmetrical curcumin derivative, 5-methoxycurcumin (47) from C. xanthorrhiza (40). 

Saito M., Hirose F. and Okochi H. (1995) Comparative study of the determination of micro-amounts of boron in high-purity molybdenum by a spectrophotometric method using curcumin, spark source mass spectrometry and glow discharge mass spectrometry, Anal Sci 11 695-697. 

There are several good sources of curcumin with purity ranging from 60 to 98% (Table... 

Fig. 1. Inhibitory effect of apigenin, quercetin, naringenin, curcumin and resveratrol on the prostaglandin (PG)E2 production of the macrophage stimulated by lipopolysaccharide (LPS). Source Reference 23.

Polyphenols, such as curcumin, quercetin and resveratrol, are some examples of naturally occurring phytochemicals with proven antioxidant and anti-inflammatory activity, beneficial cardiovascular effects," antiatherosclerotic effects, chemopreventive, and anticarcinogenic effects. An abundance of mechanistic information has become available on how polyphenols derived from dietary sources, which have putative chemopreventive properties, interfere with tumor promotion and progression. The effect of these bioactive compounds on the organism is influenced by their bioavailability, namely, their ability to be effectively absorbed by the human body. However, the polyphenols have a poor bioavailability and are rapidly metabolized by human body, losing their potential beneficial effects. ... 

Hydroxycurcumin [l-hydroxy-l,7-bis(4-hydroxy-3-methoxyphenyl)-(6 -6-heptene-3,5-dione] m 84-88 was isolated from the same source, had UV at 372nm in MeOH and had a weaker antioxidant activity than the other curcumins towards the autoxidation of linoleic acid in a water-alcohol system [Masuda et al. Phytochemistry 31 3645 1992]. An optically active form, (l -l-hydroxy-l,7-bis(4-hydroxy-3-methoxyphenyl)-(lE,6E)-l,6-heptadiene-3,5-one, has m 92.0-96.0 , with [a]o +12.2 (c 0.06, EtOH, configuration unknown), M 386.4. Its UV has Imsix nm (e)(MeOH) at 230 (sh), 260 (21000), 283 (18000),... 

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