Crossfire retrievals

Overall, the data from gamma-sterilized liners (Figures 22.10-22.12), combined with evidence from Crossfire retrievals (Chapter 14), all point to a similar scenario in which the femoral head reduces the in vivo oxidation of polyethylene at the bearing surface [18]. Consequently, provided rim impingement does not occm and the polyethylene locking mechanisms remain relatively isolated from oxidizing fluid, in vivo oxidation does not appear to be clinically important in the first 10 years of implantation for conventional ganuna sterilized polyethylene. Recently,... 

This tutorial, which is based on the Beilstein update BS0202PR (May, 2002) and on the retrieval program Cro.ssFire Commander V6,. shows. some typical advanced search examples in the Beilstein database. It is assumed that the user already knows some of the basic features of the retrieval program. Moreover, in this tutorial the CrossFire Structure Editor is used instead of the (SIS/Draw Structure Editor. The first example is a combined application of structure aiM fact retrieval, whereas the second example demonstrates reaction retrieval. 

Figure 5-19. CrossFire Corrunander V6 with a coinbined structure and fact retrieval here only the end of the fact requirement can be seen.

Figure 5-22. CrossFire Commander V6 for the refinement of a pr retrieval by means of a fact search.

References to data retrieved from a stand-alone database should cite the source as a computer program (for example, MDL CrossFire Commander, see p 323 f) or as an online reference book (for example, the Kirk-Othmer Encyclopedia of Chemical Technology, see p 305 f), with the data entry number or other identifying information included at the end of the citation. Data retrieved from an Internet-based database should cite the source as a Web site (see pp 316 ff). If the data retrieved are calculated data, also cite the software used for calculation (for example, ACD/Labs). 

Many chemists therefore take the view that the Beilstein and Gmelin files may be regarded as factual files, while the CAS and Derwent files are not. In the sense of the approach of the present article, this is certainly unfair to the latter pair, It is certainly true that in particular cases the generalized description of a property described in a generalized way in the abstract of a document may lead to valuable results which would be difficult or impossible to obtain without this form of soft data retrieval. For this very reason, Beilstein s CrossFire system has now started to include more and more soft data in the form of abstracts, titles, and other qualitative free text in its databases. 

Many producers and public hosts offer reduced rates for academics or full academic programs , making expensive retrieval systems and databases affordable for academic institutions (e.g., MDL, retrieval system ISIS plus several databases Beilstein Information Systems, CrossFire FIZ Chemie, reduced rates for both Cheminform RX in house and at the host STN Springer/Infochem Synopsys). However, CASREACT is unfortunately not included at this time in the otherwise very useful CAS academic program. ... 

In a report on 12 retrieved Crossfire components, six of the retrievals exhibited fatigue damage, but five had signs of impingement [32]. None of the components was revised for wear, fatigue, or failure of the locking mechanism. Implantation times ranged from 0.1 to 5.3 years. No other... 

Fifty-seven Crossfire liners were retrieved during consecutive revision surgeries at a single, high-volume institution [35]. 

Clinical studies are underway for X3 at both the hip and knee. Two-year wear results are expected during late 2008 for the hip. At this short follow-up time the penetration is dominated by creep it will not be until 5-year results are available that a realistic comparison can be made to the wear of N2A ac and to Crossfire. Knee clini-cals are focused on clinical variables because there is no accepted methodology for in situ knee wear measurement. However, wear can be measured using retrievals. Retrieval analysis is ongoing as components become available. Oxidation and mechanical properties are being determined so that the in vivo performance of X3 can be compared to that of the earlier generation UHMWPEs. 

Currier BH, Currier JH, Mayor MB, Lyford KA, Collier JP, Van Critters DW. Evaluation of oxidation and fatigue damage of retrieved Crossfire polyethylene acetabular cups. J Bone Joint Surg Am 2007 89(9) 2023-9. 

Kurtz SM, Hozack WJ, Turner J, Purtill J, MacDonald D, Sharkey P, Parvizi J, Manley MT, Rothman RH. Mechanical properties of retrieved highly crosslinked (Crossfire) liners after short-term implantation. J Arthroplasty 2005 20(7) 840-9. 

Kurtz SM, Austin M, Azzam K, Sharkey P, MacDonald D, Medel FJ, Hozack WJ. Mechanical properties, oxidation and clinical performance of retrieved highly cross-linked crossfire liners after intermediate-term implantation. J Arthroplasty 2008. (In Press). 

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