Short-term implantation

Although short-term implantation studies do give an analysis of the biocompatibility of a material at a local site systemic effects can also be observed from corrosion products that develop from vascular implants that migrate to other sites (26). 

Biomechanical compliance or impedance matching of the tissue/material interface is not important for short-term implant experiments. However, for long implanting periods, cyclic fatigue failure of the tissue/material interface is caused by compliance mismatching. 

Frayssinet P, Gineste L, Conte P, Fages J, Rouquet N. Short-term implantation effects of a DCPD-based calcium phosphate cement. Biomaterials 1998 19(11-12) 971-977. 

An example of a radiograph from a short-term implanted PTFE LFA is shown in Figure 4.4. Figure 4.4 shows the initial orientation of the PTFE cup... 

Kvist, P.H., et al. Biocompatibility of an enzyme-based, electrochemical glucose sensor for short-term implantation in the subcutis. Diabetes Technol Ther. 8(5), 546-559 (2006)... 

By examining the polymeric materials which are currently used in cHnical application it can be seen that while their mechanical properties satisfy requirements, their total compatibility with blood has still not been achieved. Therefore, commercial polymers like polyurethanes, siHcones, polyolefins and poly(vinyl chloride) which are used as short-term implant materials show thrombogenic properties and require the introduction of anticoagulants [26,43]. 

This definition was, in 2003, further revised using the subgroups of long-term implants, short-term implants, and tissue engineered products [3]. 

Polyamide 66 is classified as hemocompatible. For applications as short-term implants, aliphatic polyamides exhibit sufficient biocompatibility. However, degradation takes place after a longer time in vivo [978]. 

Kurtz SM, Hozack WJ, Turner J, Purtill J, MacDonald D, Sharkey P, Parvizi J, Manley MT, Rothman RH. Mechanical properties of retrieved highly crosslinked (Crossfire) liners after short-term implantation. J Arthroplasty 2005 20(7) 840-9. 

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