Cortisone injection

Sidwell RW, Thorpe BD, Gebhardt LP. Studies of latent Q fever infections, II Effects of multiple cortisone injections. Am J Hyg. 1964 79 320-327. 

Although cortisone interferes with protein synthesis in peripheral tissue, the hormone stimulates protein synthesis in liver. The increased rate of protein synthesis results from an effect of the hormone on the penetration of the amino acid through the cell membrane. The effects of the steroid hormones on the amino acid penetration were demonstrated with the aid of a-aminoisobutyric acid, a nonmetabolizable amino acid the intracellular penetration of which is regulated by mechanisms similar to those controlling glycine penetration. The penetration of a-aminoisobu-tyric acid is competitively inhibited by valine. Two hours after the injection of cortisol, the aminoisobu-tyric acid content of the liver is increased 70%. The increase in amino acid uptake may explain the increase of protein synthesis in liver observed early after cortisone injection. In that connection, it is of interest that an accelerated turnover of serum albumin has been reported early after the injection of cortisone. Since the concentrations in the levels of the blood protein are not changed, it seems that increased synthesis only compensates for increased catabolism. 

As a result of experiments on puffing inhibition in the polytenic chromosomes of Sciaria corpophila due to cortison injection, it was found that puffing is not necessary for normal development (Goodman et al., 1967). 

An injection of the steroid cortisone (Section 26 14) IS often effective for reducing the pain and inflammation that comes from an injury But chronic pain and inflammation such as occurs with arthritis is better managed with an orally ad... 

System (4) has been reported for the simultaneous determination of cortisol and cortisone in human plasma by stable-isotope dilution-MS [178]. For the determination, capillary GC-MS with H5 -cortisol and H5 -cortisone (as internal standards) was used. The method used a SPB-1 fused-silica capillary column (7 m x 0.25 mm) and helium as the carrier gas (at 29.4 Pa), with 70 eV EIMS being used for selective-ion monitoring. The concentrations were determined from the peak height ratios of the [M-31] fragment ions of the methoxime-TMS derivatives of cortisol, cortisone, and their internal standards. The sensitivity of the method was 200 pg per injection for both cortisol and cortisone. 

Cortisone acetate injectable formulations have been reported to be incompatible with various drugs, but the compatibility depends on several factors (such as drug concentrations, resulting pH, temperature, etc.). Specialized references should be consulted for specific incompatibility information [61]. 

Parenteral 4 mg/mLfor IV, IM, intralesional, or intra-articular injection Cortisone (generic, Cortone Acetate)... 

Intraaraticular injections of cortisone are used to alleviate the pain from osteoarthritis, especially in the knee, elbow and hands. 

Ionita IA, Akhlaghi F (2010) Quantification of unbound prednisolone, prednisone, cortisol and cortisone in human plasma by ultrafiltration and direct injection into liquid chromatography tandem mass spectrometry. Ann Clin Biochem 47 350-357... 

Cortisone acetate is rapidly effective when given orally, and more slowly by intramuscular injection. Cortisone acetate has been used in the treatment of many of the allergic and inflammatory disorders for which corticosteroid therapy is helpful but prednisolone or other synthetic glucocorticosteroids are generally preferred. 

Figure 10 CEC-UV chromatogram (240 nm) of a mixture of 10 corticosteroids (100 qg/mL) using a linear gradient elution program. Voltage = 30 kV, HPLC injection volume = 10 pL, flow-rate = 10 pL/min for 3 min, then decreased to 100 pL/ min. Gradient program = initial ammonium acetate, 5 mM, in acetonitrile/water (17/83), held for 3 min, then ramped to 38% acetonitrile at 15 min and maintained to end of run. Column = Hypersil ODS, 3 pm, 42 cm total length, 30 cm packed length, 30.1 cm to window, 1 = triamcinolone, 2 = hydrocortisone and prednisolone co-eluting, 3 = cortisone, 4 = methylprednisolone, 5 = betamethasone, 6 = dexamethasone, 7 = adrenosterone, 8 = fluocortolone, 9 = triamcinolone aceto-nide. (Reprinted from Ref. 57, with permission.)...

T3. Thomas, L., Reversible collapse of rabbit ears after intravenous injection of papain, and prevention of recovery by cortisone. /. Exptl. Med. 104, 245-252 (1956). 

Studies undertaken to study the role of other endocrine activity in these changes showed that injections of norepinephrine and ACTH decreased the rate of production of testosterone and lowered the plasma level. Injections of cortisone alone had no effect on blood testosterone levels (C2). 

Local injection can be effective, e.g. into the affected region in tendinitis, or sometimes intrathecally. Systemic administration is normally reserved for short-term use or emergencies, such as anaphylactic shock. Examples of this type include betamethasone, clobetasol, cortisone, hydrocortisone, prednisolone and triamcinolone. 

Cortlsyl cortisone, cortivazol (inn. usan) (H 3625 MK 650) is a CORTICOSTEROID, a GLUCOCORTICOID with ANTIINFLAMMATORY and ANTIALLERGIC properties. It has been used orally and by injection to treat inflammatory conditions. 

Our own study examined the effects of a mixture of fatty acids on cortisol and cholesterol levels in laboratory stress situations. (Yehuda, al el, 2000). A compound of free nonesterified unsaturated fatty acids a-linolenic and linolenic acids in a ratio 1 4 was administered for 3 wk prior to injection of cortisone (10 mg/kg) or prior to immersion of rats in a 10°C saline bath. The results confirmed the expected elevation of cortisol and cholesterol level in stress, but, more importantly, the treatment prevented elevation of blood levels of cortisol and cholesterol and protected against deficits in the Morris water maze learning that usually accompany such stressful conditions. Differences from con-... 

The role of the adrenal gland in various responses to various stresses has been widely studied. John (Jl) found that sound stress for a period of 1.5 hours produced marked lymphocytopenia in normal but not adre-nalectomized rats. Estimating the normal daily in vivo production of corticoid to be equivalent to 0.8 j ,g of cortisone acetate per kilogram body weight injected subcutaneously as an aqueous suspension, Johns noted that injection of 4.0 mg of cortisone acetate per 100 g body weight into adrenalectomized rats resulted in lymphocytopenia. Injection of doses of cortisone acetate more equivalent to the normal daily secretion of corticoid in intact animals did not produce lymphocytopenia in adrenalectomized rats, but did restore the lymphocytopenic response to sound stress. 

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