Antiallergic properties

Noradrenaline and adrenaline increase blood pressure, although in various organs the perfusion can actually be reduced. Since adrenaline, in contrast to noradrenaline, stimulates a-and jSi-adrenoceptors and the jSi-subtype as well, its vascular effects are more complex than those of noradrenaline. In many vessel beds like the splanchnic area and the skin the O -adrenoceptor-mediated vasoconstriction is dominant. However, in others, like the active skeletal muscles, the jS2-adrenoceptor-mediated vasodilatation increases the blood flow. In the lower concentration range adrenaline induce an increase in blood pressure without elevated diastolic values. Catecholamines reduce the permeability of the vascular endothelium which might be of some importance for their antiallergic properties. 

A -cortisol prednisolone, cortisone (ban. inn] (cortisone acetate [usan] Kendall s compound E Reichstein s Substance Fa Wintersteiner s compound F NSC 9703 Cortisyl ) is a natural adrenal cortical hormone, a CORTICOSTEROID, which is converted to hydrocortisone in the liver. It has both GLUCOCORTICOID and MINERALOCORTICOID activity. It can therefore be used orally to make up for hormonal deficiency (especially mineral balance), for instance, following surgical removal of the adrenal glands. It can also be used for its ANTIINFLAMMATORY and ANTIALLERGIC properties in treating rheumatoid arthritis and in rheumatic fever therapy, cortisone acetate cortisone. 

Cortlsyl cortisone, cortivazol (inn. usan) (H 3625 MK 650) is a CORTICOSTEROID, a GLUCOCORTICOID with ANTIINFLAMMATORY and ANTIALLERGIC properties. It has been used orally and by injection to treat inflammatory conditions. 

Dexacort dexamethasone. dexamethasone [ban, inn] (dexamethasone acetate, [usan] dexamethasone acefurate [inn] dexamethasone sodium phosphate [usan] dexamethasone pivalate dexamethasone phosphate dexamethasone metasulphobenzoate [ban] Dexacort Decadron Hexadrol Stiedex and many other names) is a potent CORTICOSTEROID, a GLUCOCORTICOID with ANTIINFLAMMATORY and ANTIALLERGIC properties. It is used topically to treat severe, non-infective inflammation of the skin caused by conditions such as eczema and psoriasis. It can be used systemically or orally for adrenocortical insufficiency, dexamethasone acefurate dexamethasone. dexamethasone acetate dexamethasone. dexamethasone phosphate dexamethasone. dexamethasone pivalate dexamethasone. dexamethasone metasulphobenzoate dexamethasone. 

Roccal benzaikonium chloride, rocepafant [inn] (BN S0730) is a complex diazepine. a PLATELET-ACTTVATING FACTOR RECEPTOR ANTAGONIST. It haS ANTIALLERGIC properties, experimental antiarthritic activity, and has been investigated for treatment of drug-induced retinopathy. 

Audicort Aureocort Aristocort Kenalog Ledercort ) is a corticosteroid, a glucocorticoid with ANTIINFLAMMATORY and ANTIALLERGIC properties. It is most commonly used in the form of the acetonide, to suppress the symptoms of inflammation, especially when it is caused by allergic disorders. It is sometimes used systemically to relieve conditions such as hay fever and asthma. It is commonly given by local injection to treat skin inflammation due to rheumatoid arthritis and hursitis. There are a number of topical preparations to treat severe, non-infective skin inflammation, such as eczema, or for treating inflammation in the mouth and ears. 

Glucocorticoids also have antiallergic properties, as a result of and by an inhibition of the synthesis of histamine by mast cells and basophils. Of the naturally occurring corticosteroids, only cortisol and corticosterone possess glucocorticoid activity, with cortisol the most effective. Cortisone and 11-dehydrocorticosterone lack direct glucocorticoid activity, but have potential glucocorticoid activity because they can be metabolixed to cortisol and corticosterone, respectively. 

In recent studies, 4(3H)-Quinazolinone derivatives have been reported to possess both antimicrobial and antiallergic properties [25], In a cell culture study, 6-Bromo-2-phenyl-3-[(4-amino-5-(4-chlorophenyl)-6-ethylpyrimidin-2-yl]-4(3H)-quinazolinone exhibited antiviral activity against VACV in E6SM cell culture at a concentration of 1.92 pg/mL. 

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