Controlled delivery of bioactive molecules

Halloysite Nanotubules, a Novel Substrate for the Controlled Delivery of Bioactive Molecules... 

The selective activation of compounds with potential therapeutic effects and the controlled delivery of bioactive molecules triggered by light are topics of intensely growing interest (6,197-200). Besides the search for light-sensitive prodrugs activated by photochemical cleavage, isomerization or photoredox processes (201-203), especially the release of small molecules such as NO, CO, CS2, and H2S, have attracted a lot of interest in the past years (204-208). 

Chitosan-dextran sulfate Nanoparticles For controlled delivery of bioactive molecules and cells in bone regeneration [16]... 

Valente JFA, Caspar VM, Antunes BP, Countinho P, Correia U. Microencapsulated chitosan-dextran sulfate nanoparticles for controlled delivery of bioactive molecules and cells in bone regeneration. Polymer. 2013 54(1) 5-15. 

Young S, Wong M, Tabata Y et al (2005) Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 109 256-274... 

Cohen and co-workers combined the unique characteristics of acetyl-dextran (Ac-DEX) and spermine with small interfering RNA - a class of double-stranded RNA molecules, 20-25 base pairs in length - as a delivery system. Ac-DEX possesses several characteristics suitable for the delivery of bioactive agents such as proteins. The novel system combined ease of synthesis and biocompatibility with the advantage of controlled release, i.e., sensitivity to physiologically relevant acidic conditions. Acid-catalysed hydrolysis of spermine-Ac-DEX generated spermine-modified dextran, which could be further metabolised in vivo by enzymes [13]. 

In 2004, Barbe and coworkers reviewed sol-gel miCToencapsulation of bioactive molecules for drug-delivery. Four years later, the same team published a first summary of their studies on silica-based microparticles doped with hydrophilic molecules obtained from water-in-oil (W/O) microemulsions. The Australian scientists showed how both the particle size and the release rate of silica-based microparticles can be finely and easily tailored in a wide range by controlling the conditions affecting the sol-gel process. In 2006, van Driessche and Hoste published the first account on the topic in a book addressing microencapsulation techniques, mainly covering the findings of Barbe and cowoikers. 

Delivery vehicle Several TE strategies involve the use of biomaterials as reservoirs for controlled drug dehvery of bioactive molecules. These molecules can act as chemoattractants that foster ceU colonization of the scaffold as well as promote stem cell differentiation toward a specific hneage. The choice of the biomaterial and its fabrication process should not have a detrimental effect on drug availability and bioactivity. ... 

---