Controlled delivery of bioactive

Halloysite Nanotubules, a Novel Substrate for the Controlled Delivery of Bioactive Molecules... 

The selective activation of compounds with potential therapeutic effects and the controlled delivery of bioactive molecules triggered by light are topics of intensely growing interest (6,197-200). Besides the search for light-sensitive prodrugs activated by photochemical cleavage, isomerization or photoredox processes (201-203), especially the release of small molecules such as NO, CO, CS2, and H2S, have attracted a lot of interest in the past years (204-208). 

The preliminary results of a recent study on expanded Teflon vascular grafts show that certain gel-formers can be used as sealants for these microporous implants. As sealants, they can also be used as carriers for the controlled delivery of bioactive agents to prolong patency of the grafts. 

Controlled Release Society. 3650 Annapolis Lane North, Suite 107, Minneapolis, MN 55447, U.S.A. Phone +1 763-512-0909, Fax +1 763-765-2329. E-mail director controlledrelease.org. URL http //www.controlledrelease.org. The Controlled Release Society (CRS) is an international organization which serves 3000 members from more than 50 countries. Two-thirds of the CRS membership represents industry and one-third represents academia and government. The organization is dedicated to improving quality of life by advancing science, technology, and education in the field of controlled delivery of bioactive substances. CRS publishes the Journal of Controlled Release and sponsors several meetings, workshops, and symposia. 

Gel-forming (GF) absorbable copolyesters made by end-grafting one or more cyclic monomer onto a polyalkylene glycol, such as polyethylene glycol for use in tissue repair and controlled delivery of bioactive agents... 

Apart from these advantages, the main disadvantages of these polymers are their short-term degradation and release period, and the need for special storage conditions (refrigeration, dry conditions). Thus, these polsrmers are most suitable for short-term (days to weeks) controlled delivery of bioactive agents in the form of solid implants or injectable microspheres. 

Briganti, E., Spiller, D., Mirtelli, C., KuU, S., Counoupas, C., Losi, P., Senesi, S., Di Stefano, R., Soldani, G., 2010. A composite fibrin-based scaffold for controlled delivery of bioactive pro-angiogenetic growth factors. Journal of Control Release 142,14—21. 

Chitosan-dextran sulfate Nanoparticles For controlled delivery of bioactive molecules and cells in bone regeneration [16]... 

Valente JFA, Caspar VM, Antunes BP, Countinho P, Correia U. Microencapsulated chitosan-dextran sulfate nanoparticles for controlled delivery of bioactive molecules and cells in bone regeneration. Polymer. 2013 54(1) 5-15. 

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