Contraceptive “pill

Has the properties of progesterone and is given orally for treating functional uterine haemorrhage. Norethisterone, 19-norelhisterone, m.p. 20I-206°C is one of the progestational steroids used in the contraceptive pill. 

Exposure to estrogenic compounds through diet will differ for herbivores and carnivores, the latter being most likely to encounter endogenous steroids in their prey. Efficient uptake of steroids in mammals is illustrated by the use of the contraceptive pill, but routes of absorption in invertebrates remain to be determined. The relationship between endocrine disruption and metabolic toxicity, with reduced reproductive viability a secondary consequence of metabolic disturbance, also merits further study in invertebrate species. 

In monophasic preparations a fixed estrogen/progestin combination is present in each contraceptive pill. 

Drug therapy Estrogen-containing oral contraceptive pills Estrogen replacement therapy SERMs HIT... 

A 25-year-old Caucasian woman presents to the university student clinic with complaints of intermittent crampy abdominal pain and four to five loose stools per day. She describes some visible mucus and blood in the stool and states that these symptoms have been present for 6 to 8 weeks. She also has intermittent lower back pain, fatigue, fever, and a 10-lb (4.5 kg) weight loss. The back pain started about the same time as her gastrointestinal symptoms. She denies any sick contacts and has not eaten any take-out or restaurant food over the last 2 months. She takes nonprescription naproxen as needed for aches and pains. She has been using more naproxen recently because of the back pain. She also takes an oral contraceptive pill once daily. She consumes alcohol socially and currently smokes 1/2 to 1 pack of cigarettes per day. 

In addition to preventing pregnancy, there are several noncontraceptive benefits associated with the use of combined oral contraceptive pills. Many of the potential non-contraceptive benefits are highlighted below. 

As an alternative to oral contraceptive pills, which must be taken daily in order to reliably prevent pregnancy, non-oral contraceptives in the form of transdermal, transvaginal, and injectable preparations are available and offer patients safe and effective alternatives to the pills for prevention of pregnancy. These formulations also do not require daily administration, making them more convenient than the pill formulations. 

Data from Hatcher RA, Trussel i Stewart F, et at. Contraceptive Technology, 8th ed. New York Ardent Media, 2004 Dickey RP. Managing Contraceptive Pill Patients, 12th ed. Dallas, IX Essential Medical Information Systems, 2004. 

Like the medical treatment of uterine leiomyomas, danazol, gestrinone, mifepristone, and GnRH-a, with or without add-back therapy, have been proposed for the treatment of endometriosis as well (Olive et al. 2001 Stones et al. 2004), but unlike leiomyomas, oral contraceptive pills, in cyclic or continuous administration, and medroxyprogesterone acetate also seem to be effective (Olive et al. 2001 Stones et al. 2004). A significant benefit in terms of pelvic pain relief also is obtained with the use of nonsteroidal anti-inflammatory drugs (Olive et al. 2001 Stones et al. 2004). 

One potentially serious consequence of enz)rme induction relates to the oral contraceptive pill (OCP), which may be rendered ineffective by induction of its metabolism. The effect of a period of drug administration on circulating... 

Studies on isolation from adrenal cortex and the synthesis of cortisone (in 28 steps), an anti-arthritic hormone, was accomplished in the 1940s by Woodward and others. Cortisone was used as an important military medicine during World War II. Carl Djerassi from Stanford University directed the research at the Syntex Laboratories, which led to the synthesis of the first oral contraceptive pill for women. Koji Mori is very active in the field of the synthesis of pheromones. 

Emergency contraception (Plan B and Proven only) For prevention of pregnancy following unprotected intercourse or a known or suspected contraceptive failure. To obtain efficacy, take the first dose as soon as possible within 72 hours of intercourse. The second dose must be taken 12 hours later. Emergency contraceptive pills are not indicated for ongoing pregnancy protection and should not be used as a woman s routine form of contraception. 

NS normal saline NSAID nonsteroidal antiinflammatory drug NSCLC non small cell lung cancer NSS normal saline solution NYHA New York Heart Association OAB overactive bladder OCD obsessive-compulsive disorder OCP oral contraceptive pill (birth control pills)... 

The major oestrogen preparations used medically are outlined in Table 1.12, and their chemical structure is illustrated in Figure 1.3. The widest clinical application of oestrogens relate to their use as oral contraceptives. Most such contraceptive pills contain an oestrogen in combination with a progestin (discussed later). 

So far no simple equivalent of the oral contraceptive pill has been developed for men. Relatively large doses of testosterone do inhibit gonadotrophin secretion and hence spermatogenesis, and different schedules are under clinical trial at present. 

The term induction has evolved to include any mechanism that results in increased tissue concentration of catalytically active protein involved in drug metabolism. This increased enzyme activity results in greater systemic clearance and lower bioavailability of extensively metabolized drugs. The resulting lower drug concentrations often result in therapeutic failure. For example, it is well known that oral contraceptive pills become ineffective when rifampin is coprescribed. 

The introduction of the sulfa drugs was followed by the development of the penicillin antibiotics. Fleming s chance observation of the anti-bacterial action of the penicillin mold in 1928 and the subsequent isolation and identification of its active constituent by Florey and Chain in 1940 marked the beginning of the antibiotics era that still continues today. At roughly the same time, the steroid hormones found their way into medical practice. Cortisone was introduced by the pharmaceutical industry in 1944 as a drug for the treatment of arthritis and rheumatic fever. This was followed by the development of steroid hormones as the active constituents of the contraceptive pill. 

---