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Condensation of acetone

DIBK can be produced by the hydrogenation of phorone which, in turn, is produced by the acid-catalyzed aldol condensation of acetone. It is also a by-product in the manufacture of methyl isobutyl ketone. Diisobutyl ketone ( 1.37/kg, October 1994) is produced in the United States by Union Carbide (Institute, West Virginia) and Eastman (Kingsport, Teimessee) (47), and is mainly used as a coating solvent. Catalytic hydrogenation of diisobutyl ketone produces the alcohol 2,6-dimethyl-4-heptanol [108-82-7]. [Pg.493]

Methyl Amyl Ketone. Methyl amyl ketone [110-43-0] (MAK) (2-heptanone) is a colorless Hquid with a faint fmity (banana) odor. It is found in oil of cloves and cinnamon-bark oil, and is manufactured by the condensation of acetone and butyraldehyde (158). Other preparations are known (159-162). [Pg.493]

Methyl Isoamyl Ketone. Methyl isoamyl ketone [110-12-3] (5-methyl-2-hexanone) is a colorless Hquid with a mild odor. It is produced by the condensation of acetone and isobutyraldehyde (164) in three steps which proceed via the keto-alcohol dehydration to 5-methyl-3-hexen-2-one, and hydrogenation to 5-methyl-2-hexanone. [Pg.493]

Mesityl oxide can also be produced by the direct condensation of acetone at higher temperatures. This reaction can be operated ia the vapor phase over 2iac oxide (182), or 2iac oxide—2irconium oxide (183), or ia the Hquid phase over cation-exchange resia (184) or 2irconium phosphate (185). Other catalysts are known (186). [Pg.494]

Ma.nufa.cture. Isophorone is produced by aldol condensation of acetone under alkaline conditions. Severe reaction conditions are requited to effect the condensation and partial dehydration of three molecules of acetone, and consequendy raw material iaefftciency to by-products is limited by employing low conversions. Both Hquid- and vapor-phase continuous technologies are practiced (186,193,194). [Pg.494]

Pentanedione can also be produced by the condensation of acetone with ethyl acetate (312—317), or by the condensation of ethyl acetoacetate and ketene (318—321). Other methods are known (322,323). [Pg.499]

Other Processes. Isopropyl alcohol can be prepared by the Hquid-phase oxidation of propane (118). It is produced iacidentaHy by the reductive condensation of acetone, and is pardy recovered from fermentation (119). Large-scale commercial biological production of isopropyl alcohol from carbohydrate raw materials has also been studied (120—123). [Pg.111]

Kelkar and McCarthy (1995) proposed another method to use the feedforward experiments to develop a kinetic model in a CSTR. An initial experimental design is augmented in a stepwise manner with additional experiments until a satisfactory model is developed. For augmenting data, experiments are selected in a way to increase the determinant of the correlation matrix. The method is demonstrated on kinetic model development for the aldol condensation of acetone over a mixed oxide catalyst. [Pg.143]

An acridine with a radically different substitution pattern, interestingly, still exhibits antimalarial activity. Condensation of acetone with diphenylamine in the presence of strong acid affords the partly reduced acridine, 20. Alkylation with 3-chloro-dimethylaminopropane (via the sodium salt of 20) affords dimethacrine (21). ... [Pg.397]

The residue of the ether solution is fractionally distilled under a reduced pressure and the fraction is collected, which boils under a pressure of 12 mm. at a temperature of from 138° to 155° C. and from it the unattacked oitral and unchanged acetone and volatile products of condensation of acetone by itself are separated in a current of steam, which readily carries off these bodies. [Pg.219]

Examples Compound <35) is a double diene, capable of Diels-Alder reactions on the simple diene and on the furan ring and it was required to try out a route to polycyclic compounds using both these reactions, Wittig disconnection direct to available aldehyde (36) and easily made (37) is possible, but the alternative Wittig disconnection to (38) takes advantage of the known simple and high yielding condensation of acetone with (36). [Pg.220]

As in the case of homogeneous acids as catalyst, we would also benefit from using solid ba.ses instead of dissolved bases as catalyst. A number of industrially important reactions are carried out with bases as catalyst. A well know example is the aldol condensation of acetone to diacetone alcohol, where dissolved NaOH in ethyl alcohol is u.sed as a catalyst at about 200 to 300 ppm level. However, heterogeneous pelleted sodamide can be used as a catalyst for this reaction and it obviates the problem of alkali removal from the product, which would otherwise lead to reversion of diacetone alcohol to acetone during distillation of the product mixture. [Pg.138]

The complex [Co(NH3)5(OS02CF3)]2+ undergoes triflate substitution by cyanate and condensation with acetone to form the unusual bis-bidentate imine complex (213)917 in a reaction reminiscent of the classic Curtis condensation of acetone with ethylenediamine. Apart from the novelty of the synthesis, the reported crystal structure was only the second of a CoN6 complex bearing a cyanate ligand. [Pg.79]

A CD process for the production of DAA from acetone was developed previously in our laboratory and the kinetics of the aldol condensation of acetone were characterized (13,14). CD is a green reactor technology that provides enhanced yield and selectivity in addition to significant energy savings (15). The one-step synthesis of MIBK by CD appears to be a simple extension of this process. However, the introduction of hydrogen to this system opens... [Pg.262]

The Aldol Condensation of Acetone Over a CsOH/Si02 Solid Base Catalyst... [Pg.363]

The solid base catalysed aldol condensation of acetone was performed over a CsOH/Si02 catalyst using a H2 carrier gas. The products observed were diacetone alcohol, mesityl oxide, phorone, iso-phorone and the hydrogenated product, methyl isobutyl ketone. Deuterium tracer experiments were performed to gain an insight into the reaction mechanism. A mechanism is proposed. [Pg.363]

The aldol condensation of acetone to diacetone alcohol is the first step in a three-step process in the traditional method for the production of methyl isobutyl ketone (MIBK). This reaction is catalysed by aqueous NaOH in the liquid phase. (3) The second step involves the acid catalysed dehydration of diacetone alcohol (DAA) to mesityl oxide (MO) by H2S04 at 373 K. Finally the MO is hydrogenated to MIBK using Cu or Ni catalysts at 288 - 473 K and 3- 10 bar (3). [Pg.363]

The reaction mechanism is shown in Figure 4 and is adapted from work by Fiego et al. [9] on the acid catalysed condensation of acetone by basic molecular sieves. The scheme has been modified to include the hydrogenation of mesityl oxide to MIBK. The scheme begins with the self-condensation of acetone to form diacetone alcohol as the primary product. The dehydration of DAA forms mesityl oxide, which undergoes addition of an addition acetone to form phorone that then can cyclise, via a 1,6-Michael addition to produce isophorone. Alternatively, the mesityl oxide can hydrogenate to form MIBK. [Pg.368]

The condensation of acetone can also occur over acidic sites as shown by a number of authors [1,9], Generally, when this occurs other products are formed such as isobutene and acetic acid, by the cracking of DAA. Additionally mesitylene can be formed by the internal 2,7-aldol condensation of 4,6-dimethylhepta-3,5-dien-2-one which is in turn obtained by the aldol condensation of MO with a deprotonated acetone molecule [7, 8], As these species are not observed we can concluded that any acidic sites on the silica support are playing no significant role in the condensation of acetone. [Pg.368]

The title compound, 88, the main metabolite of 13-cis-retinoic acid in mammals, has been synthesized27 as before via condensation of acetone-1,2,3-13C3 with 3,7-dimethyl-2,6-octadienal (citral), 89 (equation 33). [Pg.805]

Oxidation of primary amines with DMD or other oxidants leads to the formation of a complex mixture of nitroso, oximes, and nitro compounds (76). Utilization of DMD in acetone affords dimethyl nitrone (22). This is likely to be a result of the initial oxidation of primary amine (19) to hydroxylamine (20) with the subsequent condensation of acetone and oxidation of imine (21) (Scheme 2.9) (77). [Pg.136]

Acetylacetone has been prepared by the reaction of acetyl chloride with aluminum chloride followed by hydrolysis,3 and by the condensation of acetone with ethyl acetate under the influence of sodium,4 sodamide,5 and sodium ethoxide,5-6-7 and by the reaction of acetone and acetic anhydride in the presence of boron trifluoride.8... [Pg.6]

The condensation of acetone and 1,2-diarylbiguanides bearing identical substituents yields the same alkali-stable product (CXXXVI) under both acidic and basic conditions (95). [Pg.62]

The bicyclic tropane ring of cocaine of course presented serious synthetic difficulties. In one attempt to find an appropriate substitute for this structural unit, a piperidine was prepared that contained methyl groups at the point of attachment of the deleted ring. Condensation of acetone with ammonia affords the piperidone, 17. Isophorone (15) may well be an intermediate in this process conjugate addition of ammonia would then give the aminoketone, 16. Further aldol reaction followed by ammonolysis would afford the observed product. Hydrogenation of the piperidone (18) followed then by reaction with benzoyl chloride gives the ester, 19. Ethanolysis of the nitrile (20) affords alpha-eucaine (21), an effective, albeit somewhat toxic, local anesthetic. [Pg.27]

Recently, Di Cosimo et al. 14) investigated the self-condensation of acetone in the gas-phase at 573 K, with the catalysts being MgO or MgO promoted with alkali metal ions. On pure MgO, the acetone conversion was initially 17%, and this... [Pg.256]

Besides oxidative coupling of methane and double bond isomerization reactions (242), a limited number of organic transformations have been carried out with alkali-doped alkaline earth metal oxides, including the gas-phase condensation of acetone on MgO promoted with alkali (Li, Na, K, or Cs) or alkaline earth (Ca, Sr, or Ba) (14,120). The basic properties of the samples were characterized by chemisorption of CO2 (Table VI). [Pg.285]


See other pages where Condensation of acetone is mentioned: [Pg.450]    [Pg.94]    [Pg.99]    [Pg.493]    [Pg.493]    [Pg.350]    [Pg.8]    [Pg.233]    [Pg.231]    [Pg.201]    [Pg.450]    [Pg.264]    [Pg.364]    [Pg.366]    [Pg.368]    [Pg.368]    [Pg.370]    [Pg.372]    [Pg.4]    [Pg.307]    [Pg.362]    [Pg.252]    [Pg.286]   


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