Comparison of Insulins

Note Do not confuse Humolog, NovoLog, Humolog Mix, ond NovoLog Mix or with other ogenis o medicofion error con result. 

Note Do nor confuse Humcilog, NovoLog, Hu mcilcg Mix, cmcl NovoLog Mix or w ilh other cigente cis serious 

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Strowig SM, Aviles-Santa ML, Raskin P. Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and troglitazone in type 2 diabetes. Diabetes Care 2002 25(10) 1691-8. 

In an open comparison of insulin aspart and regular human insulin for 6 months in 882 patients with type 1 diabetes and extended to 714 patients for another 6 months, postprandial glucose concentrations were lower with insulin aspart (7). HbAic was slightly but significantly lower (7.78 versus 7.93%). There were no differences in hypoglycemic periods or adverse events. 

Hedman CA, Lindstrom T, Arnqvist HJ. Direct comparison of insulin lispro and aspart shows small differences in plasma insulin profiles after subcutaneous injection in type 1 diabetes. Diabetes Care 2001 24(6) 1120-1. 

Plank J, Wutte A, Brunner G, Siebenhofer A, Semlitsch B, Sommer R, Hirschberger S, Pieber TR. A direct comparison of insulin aspart and insulin lispro in patients with type 1 diabetes. Diabetes Care 2002 25(ll) 2053-7. 

In a 6-month, multinational, open, parallel-group comparison of insulin detemir and protamine zinc insulin in 448 patients with type 1 diabetes, the two treatments produced comparable HbAlc concentrations and fasting plasma glucose concentrations with less within-subject variation in fasting blood glucose with insulin detemir (4). The risk of hypoglycemia was 22% lower with insulin detemir and 34% lower for nocturnal hypoglycemia. 

Rosenstock J, Schwartz SL, Clark CM Jr, Park GD, Donley DW, Edwards MB. Basal insulin therapy in type 2 diabetes 28-week comparison of insulin glargine (HOE 901) and NPH insulin. Diabetes Care 2001 24(4) 631-6. 

Bode B, Weinstein R, Bell D, McGill J, Nadeau D, Raskin P, Davidson J, Henry R, Huang WC, Reinhardt RR. Comparison of insulin aspart with buffered regular insulin and insulin lispro in continuous subcutaneous insulin infusion a randomized study in type 1 diabetes. Diabetes Care 2002 25(3) 439-44. 

Comparison of insulin-dependent diabetes and non-insulin-dependent diabetes. 

Mattoo V, Milicevic Z, Malone JK, Schwarzenhofer M, Ekangaki A, Levitt LK, Liong LH, Rais N, Tounsi H Ramadan Study Group. A comparison of insulin lispro Mix25 and human insulin 30/70 in the treatment of type 2 diabetes during Ramadan. Diabetes Res Clin Pract 2003 59(2) 137-43. 

Kang S, Owens D R, Vola J P, et al. (1990). Comparison of insulin analogue B9Asp B27Glu and soluble human insulin in insulin treated diabetes. Lancet. 335 303-306. 

Homko C, Deluzio A, Jimenz C, et al. (2003). Comparison of insulin aspart and lispro Pharmacokinetic and metabolic effects. Diabetescare. 26 2027-2031. 

Chow CC, Tsang LW, Sorensen JP, Cockram CS. Comparison of insulin with or without continuation of oral hypoglycemic agents in the treatment of secondary failure in NIDDM patients. Diabetes Care 1995 18(3) 307-314. 

Yki-Jarvinen H, KauppUa M, Kujansuu E, Lahti J, Marjanen T, Niskanen L et al. Comparison of insulin regimens in patients with non-insuhn-dependent diabetes mellitus. N Engl J Med 1992 327(20) 1426-1433. 

Figure 7 shows a schematic comparison of insulin, proinsulin, IGF, and relaxin. 

Kooptiwut, S., Zraika, S., Thorbum, A., Dunlop, M., Darwiche, R., Kay, T., Proietto, J., and Andrikopoulos, S. (2002) Comparison of insulin secretory function in two mouse models with different susceptibility to 3-cell failure. Endocrinology, 143(6), 2085-2092. 

Malone, J. 1., Lowitt, S., Grove, N. P., and Shah, S. C., 1986, Comparison of insulin levels after injection by jet stream and disposable insulin syringe. Diabetes Care 9 637-640. 

Jermin EE, Hollander F, Weinstein VA. A comparison of insulin and food for stim-... 

Elmslie JL, Porter RJ, Joyce PR, Hunt PJ, Shand BI. Scott RS Comparison of insulin resistance, metabolic s5mdrome and adipo-nectin in overweight bipolar patients taking sodium valproate and controls. Aust N Z J Psychiatry 2009 43(1) 53-60. 

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