Combinatorial materials science

Potyrailo, R.A. and Amis, E J. (2004) High Throughput Analysis A Tool of Combinatorial Materials Science. Kluwer Academic Plenum Pub. Corp., New York. 

In this artide, we review the new field of combinatorial materials science. We describe in detail our particular materials exploration approach that we call the continuous compositional spread (CCS) approach. This CCS approach allows the synthesis and characterization of a major fraction of a ternary or pseudo-ternary phase spread in about 24 hours. We compare the CCS approach with other schemes for rapid materials investigations. We also provide an example of the successful application of the CCS approach in the discovery of a new high dielectric constant thin-film material, an amorphous zirconium tin titanate, aZTT. New combinatorial approaches to materials research can allow us to do studies that would not have been possible using conventional techniques. 

Meredith JC, Smith AP, Karim A, Amis EJ (2000) Combinatorial materials science for polymer thin-film dewetting. Macromolecules 33 9747-9756... 

V.M. Mirsky and V. Kulikov, Combinatorial electropolymerization concept, equipment and applications, in High Throughput Analysis A Tool for Combinatorial Materials Science, Kluwer Academic/Plenum Publishers, 2003, 431-446. 

High Throughput Screening Combinatorial Material Science... 

Jandeleit B, Schaefer DJ, Powers TS, Turner HW, Weinberg WH. Combinatorial materials science and catalysis. Angew Chem Int Ed 1999 38 2494—2532. 

In order to obtain combinatorial materials science libraries, sequential deposition must be coupled with a method to diversify the composition of small areas of the deposition surface. A moving-mask system, originally designed to obtain compositional gradients (20) and then used later for the synthesis of organic libraries (21), has been successfully and repeatedly used for this purpose. The first reported materials library LI (22) used this technique employing eight binary masks M0-M7, as shown in Fig. 11.2. 

Combinatorial synthesis of materials provides a good possibility for formation of banks of combinatorial materials (Fig. 1.1). Such banks can be used, for example, for further reinvestigation of the materials of interest for some new applications or as reference materials. However, this approach did not find wide applications yet in combinatorial materials science. 

Potyrailo, R. A. Takeuchi, I., Role of high-throughput characterization tools in combinatorial materials science, Meas. Sci. Technol. 2005, 16, 1-4... 

Cohan, P. E., Combinatorial materials science applied - mini case studies, lessons and strategies, In Combi 2002 - the 4th Annual International Symposium on Combinatorial Approaches for New Materials Discovery, Knowledge Foundation Arlington, VA, 2002... 

Amis, E. J., Combinatorial materials science reaching beyond discovery, Nat. Mater. 2004,... 

Potyrailo, R. A. Morris, W. G. Wroczynski, R. J., Acoustic-wave sensors for high-through-put screening of materials, In High Throughput Analysis A Tool for Combinatorial Materials Science-, Potyrailo, R. A. Amis, E. J., Eds. Kluwer/Plenum New York, NY, 2003 ch. 11... 

This chapter analyzes the needs for reaction monitoring and optimization in combinatorial materials science. It is demonstrated that these needs can be achieved by the combination of the advanced analytical instrumentation, the proper design of the measurement setups, and analysis of the multivariate data collected during these experiments. 

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