Collins agent

Coformycin, 2 -deoxy—see Pentostatin Colchicine synthesis, 1, 472 isothiazoles in, 6, 174 Collins reagent as oxidizing agent, 2, 170 Colour... 

Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER (2004) Oral treatment of cowpox and vaccinia virus infections in mice with ether Upid esters of ddofovir. Antimicrob Agents Chemother 48 404-412... 

Terrence Collins is the Thomas Lord Professor of Chemistry at Carnegie Mellon University who contends that the dangers of chlorine chemistry are not adequately addressed by either academe or industry, and alternatives to chlorine and chlorine processors must be pursued. He notes, Many serious pollution episodes are attributable to chlorine products and processes. This information also belongs in chemistry courses to help avoid related mistakes. Examples include dioxin-contaminated 2,4,5-T, extensively used as a peacetime herbicide and as a component of the Vietnam War s agent orange chlorofluorocarbons (CFCs) polychlorinated biphenyls (PCBs the pesticides aldrin, chlordane, dieldrin, DDT, endrin, heptachlor, hexachlorobenzene, lindane, mirex, and toxaphene pentachlorophe-... 

Wang, J., M. Pumera, M. P. Chatrathi, A. Escarpa, M. Musameh, G. Collins, A. Mulchandani, Y. Lin, and K. Olsen. Single-channel microchip for fast screening and detailed identification of nitroaromatic explosives or organophosphate nerve agents. Anal. Chem. 74, 1187-1191 (2002). 

Collen, D. (1998). Staphylokinase a potent, uniquely fibrin-selective thrombolytic agent. Nature Med. 4(3), 279-284. Collins, R. et al. (1997). Drug therapy—aspirin, heparin and fibrinolytic therapy in suspected acute myocardial infarction. N. Engl. J. Med. 336(12), 847-860. 

Because you can easily further oxidize aldehydes to carboxylic acids, you can only employ mild oxidizing agents and conditions in the formation of aldehydes. Typical mild oxidizing agents include manganese dioxide (MnO), Sarett-Collins reagent (CrO,—(CSHSN)2), and pyridinium chlorochromate (PCC),... 

LA Collins, SG Franzblau. Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob Agents Chemother 41 1004-1009,1997. 

Wang, J., Pumera, M., Collins, G.E., Mulchandani, A., Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector Anal. Chem. 2002, 74(23), 6121-6125. 

Cassells, A.C. and Collins, I.M., Characterization and comparison of agars and other gelling agents for plant tissue culture use, Acta Hort., 530, 203-210, 2000. 

Tetrakishydroxymethyl phosphonium chloride (THPC) is well established as a flame retardant agent with textiles (3). Collins (2) has suggested that THPC and urea break down to produce phosphoric acid via a phosphine oxide, phosphinic acid, and phosphonic acid. For cellulose, Collins concludes flameproofing is essentially caused by the dehydrating action of the phosphoric acid formed. 

C. Cooper and G. Collins, Separation of thiol and cyanide hydrolysis products of chemical warfare agents by capillary electrophoresis, Electrophoresis 25, 897-902 (2004). 

J. Wang, J. Zima, N. S. Lawrence, M. P. Chatrathi, A. Mulchandani, and G. E. Collins, Microchip Capillary Electrophoresis with Electrochemical Detection of Thiol-Containing Degradation Products of V-Type Nerve Agents, Anal. Chem. 76, 4721-4726 (2004). 

Trapnell CB, Klecker RW, Jamis-Dow C, Collins JM. Glucuronidation of 3 -azido-3 -deoxythymidine (zidovudine) by human liver microsomes relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid. Antimicrob Agents Chemother 1998 42(7) 1592-6. 

Therapeutic approaches directed at the CFTR channel protein are also being considered. Elucidation of the mechanism of action of the CFTR has also led to the initiation of pharmacological strategies to correct the basic defect in CFTR. Elevation of intracellular cAMP has been shown to activate many mutant forms of CFTR. Thus, agents which increase cAMP levels by stimulating adenyl cyclase or inhibiting phosphodiesterases would be useful in therapy. Similarly, phosphatase inhibitors, which increase the net phosphate groups on the CFTR, may also be useful in therapy (Collins, 1992). 

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